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Caspase 8 蛋白

(Caspase 8 (CASP8))

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008].

recommended

Caspase 8 Protein (CASP8) (AA 217-374) (His tag) (ABIN7122169)

CASP8 宿主: 人宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA

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recommended

Caspase 8 Protein (CASP8) (AA 200-496) (His tag) (ABIN7122170)

CASP8 宿主: 人宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA

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CASP8 宿主: 小鼠宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by reducing SDS-PAGE.

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Caspase 8 蛋白 by Origin

Find Caspase 8 蛋白 for a variety of species such as anti-Human Caspase 8, anti-Mouse Caspase 8, anti-Cow Caspase 8. The species listed below are among those available. Click on a link to go to the corresponding products.

Caspase 8 蛋白 by Source

Here you will find Caspase 8 蛋白 proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

Caspase 8 蛋白 by 蛋白类型

Here you can find Caspase 8 蛋白 proteins categorized by available protein types. Additional protein types can be located using our search function.

Caspase 8 蛋白 by 应用范围

Find Caspase 8 蛋白 validated for a specific application such as WB, SDS, Imm, PC. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Popular Caspase 8 蛋白

Product

Reactivity

Source

Validations

Cat. No.

Quantity

Datasheet

Caspase 8 Protein (CASP8) (AA 217-374) (His tag)

Reactivity Human

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7122169

Quantity 50 μg

Datasheet Datasheet

Caspase 8 Protein (CASP8) (AA 200-496) (His tag)

Reactivity Human

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7122170

Quantity 50 μg

Datasheet Datasheet

Caspase 8 Protein (CASP8) (AA 219-376) (His tag)

Reactivity Mouse

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7505388

Quantity 100 μg

Datasheet Datasheet

Caspase 8 Protein (CASP8) (AA 1-218) (His tag)

Reactivity Mouse

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7411414

Quantity 100 μg

Datasheet Datasheet

Caspase 8 Protein (CASP8) (AA 8-197) (His tag)

Reactivity Rat

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7392446

Quantity 100 μg

Datasheet Datasheet

Caspase 8 Protein (CASP8) (AA 7-201) (His tag)

Reactivity Human

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7414438

Quantity 100 μg

Datasheet Datasheet

Caspase 8 Protein (CASP8) (AA 385-479) (His tag)

Reactivity Human

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7400135

Quantity 100 μg

Datasheet Datasheet

Caspase 8 Protein (CASP8) (AA 217-384) (His tag)

Reactivity Human

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7392440

Quantity 100 μg

Datasheet Datasheet

Caspase 8 Protein (CASP8) (AA 25-175) (His tag)

Reactivity Cow

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7400138

Quantity 100 μg

Datasheet Datasheet

Caspase 8 Protein (CASP8) (AA 217-479) (His tag)

Reactivity Human

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN4984215

Quantity 200 μg

Datasheet Datasheet

Caspase 8 Protein (CASP8)

Reactivity Cow

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN3008677

Quantity 100 μg

Datasheet Datasheet

Caspase 8 Protein (CASP8)

Reactivity Mouse

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN3008678

Quantity 100 μg

Datasheet Datasheet

Latest Publications for our Caspase 8 蛋白

Mishra, Sharma, Sharma, Singh, Sardesai, Sharma, Mishra: "Viscum articulatum Burm. f. aqueous extract exerts antiproliferative effect and induces cell cycle arrest and apoptosis in leukemia cells." in: Journal of ethnopharmacology, Vol. 219, pp. 91-102, (2018) (PubMed).

Appukuttan, Kasseckert, Micoogullari, Flacke, Kumar, Woste, Abdallah, Pott, Reusch, Ladilov: "Type 10 adenylyl cyclase mediates mitochondrial Bax translocation and apoptosis of adult rat cardiomyocytes under simulated ischaemia/reperfusion." in: Cardiovascular research, Vol. 93, Issue 2, pp. 340-9, (2012) (PubMed).

Murakami, Tolstykh, Bao, Niu, Steuer, Bao, Chang, Espiritu, Bansal, Lam, Otto, Sofia, Furman: "Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977." in: The Journal of biological chemistry, Vol. 285, Issue 45, pp. 34337-47, (2010) (PubMed).

Chen, Xia, Fang, Hawke, Lu: "Caspase-10-mediated heat shock protein 90 beta cleavage promotes UVB irradiation-induced cell apoptosis." in: Molecular and cellular biology, Vol. 29, Issue 13, pp. 3657-64, (2009) (PubMed).

Sone, Nakagawa, Nakagawa, Takizawa, Matsumoto, Nagasaka, Tsuruga, Hiraike, Hiraike-Wada, Miyamoto, Oda, Yasugi, Kugu, Yano, Taketani: "hScrib, a human homologue of Drosophila neoplastic tumor suppressor, is a novel death substrate targeted by caspase during the process of apoptosis." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 13, Issue 7, pp. 771-85, (2008) (PubMed).

Hasegawa, Yamada, Komiyama, Hayashi, Ishibashi, Sunazuka, Izuhara, Sugahara, Tsuruda, Masuda, Takasu, Tsukasaki, Tomonaga, Kamihira et al.: "A novel natural compound, a cycloanthranilylproline derivative (Fuligocandin B), sensitizes leukemia cells to apoptosis induced by tumor necrosis factor related apoptosis-inducing ligand (TRAIL) ..." in: Blood, Vol. 110, Issue 5, pp. 1664-74, (2007) (PubMed).

Zelphati, Wang, Kitada, Reed, Felgner, Corbeil: "Intracellular delivery of proteins with a new lipid-mediated delivery system." in: The Journal of biological chemistry, Vol. 276, Issue 37, pp. 35103-10, (2001) (PubMed).

Stennicke, Salvesen: "Biochemical characteristics of caspases-3, -6, -7, and -8." in: The Journal of biological chemistry, Vol. 272, Issue 41, pp. 25719-23, (1997) (PubMed).

Patel, Gores, Kaufmann: "The role of proteases during apoptosis." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 10, Issue 5, pp. 587-97, (1996) (PubMed).

Nicholson, Ali, Thornberry, Vaillancourt, Ding, Gallant, Gareau, Griffin, Labelle, Lazebnik: "Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis." in: Nature, Vol. 376, Issue 6535, pp. 37-43, (1995) (PubMed).

Aliases for Caspase 8 蛋白

caspase 8 L homeolog (casp8.L) 蛋白
death related ced-3/Nedd2-like protein (LOC661095) 蛋白
caspase 8 (CASP8) 蛋白
caspase-8 (LOC5563818) 蛋白
caspase-8 (casp8) 蛋白
caspase-8-like (LOC100222284) 蛋白
caspase 8 (Casp8) 蛋白
caspase 8, apoptosis-related cysteine peptidase (casp8) 蛋白
ALPS2B 蛋白
CAP4 蛋白
CASP-8 蛋白
Casp-8 蛋白
casp8 蛋白
CASP8 蛋白
casp8-A 蛋白
caspase-8 蛋白
FLICE 蛋白
MACH 蛋白
Mch5 蛋白
MCH5 蛋白
xCaspase-8 蛋白
zgc:92075 蛋白

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Caspase 8 蛋白 by Origin

Caspase 8 蛋白 by Source

Caspase 8 蛋白 by 蛋白类型

Caspase 8 蛋白 by 应用范围

Popular Caspase 8 蛋白

Latest Publications for our Caspase 8 蛋白

Aliases for Caspase 8 蛋白

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