CACNA1A 产品
(Calcium Channel, Voltage-Dependent, P/Q Type, alpha 1A Subunit (CACNA1A))
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Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas, the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1A subunit, which is predominantly expressed in neuronal tissue. Mutations in this gene are associated with 2 neurologic disorders, familial hemiplegic migraine and episodic ataxia 2. This gene also exhibits polymorphic variation due to (CAG)n-repeats. Multiple transcript variants encoding different isoforms have been found for this gene. In one set of transcript variants, the (CAG)n-repeats occur in the 3' UTR, and are not associated with any disease. But in another set of variants, an insertion extends the coding region to include the (CAG)n-repeats which encode a polyglutamine tract. Expansion of the (CAG)n-repeats from the normal 4-16 to 21-28 in the coding region is associated with spinocerebellar ataxia 6. [provided by RefSeq, Mar 2010].
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Featured CACNA1A Categories
CACNA1A 抗体
High quality antibodies with extensive validation data.
CACNA1A ELISA试剂盒
Reliable ELISA kits for a wide range of species.
Recommended CACNA1A 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, IHC, IF
Validations
- (2)
Cat. No.
ABIN7175608
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Rat
Application
WB
Validations
- (1)
Cat. No.
ABIN306878
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (1)
Cat. No.
ABIN6243080
Quantity
200 μL
Datasheet
Datasheet
Recommended CACNA1A ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6965321
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6965320
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN1167089
Quantity
96 tests
Datasheet
Datasheet
Latest Publications for our CACNA1A Products
: "The Cav2.1/alpha1A (P/Q-type) voltage-dependent calcium channel mediates inhibitory neurotransmission onto mouse cerebellar Purkinje cells." in: The European journal of neuroscience, Vol. 13, Issue 10, pp. 1902-12, (2001) (PubMed).: "Vascular smooth muscle cells express the alpha(1A) subunit of a P-/Q-type voltage-dependent Ca(2+)Channel, and It is functionally important in renal afferent arterioles." in: Circulation research, Vol. 87, Issue 10, pp. 896-902, (2000) (PubMed).
Synonyms and alternative names related to CACNA1A
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit S homeolog (cacna1a.S), calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, a (cacna1aa), calcium voltage-gated channel subunit alpha1 A (CACNA1A), calcium voltage-gated channel subunit alpha1 A (Cacna1a), calcium channel, voltage-dependent, P/Q type, alpha 1A subunit (Cacna1a), P/Q-type voltage-gated calcium channel alpha1A subunit ChCaChA1A (LOC395892), alpha1A, APCA, BccA1, BI, ca(v)2.1, Caca1a, CACH4, CACN3, cacna-a, cacna1a, CACNL1A4, Cacnl1a4, cav2.1, Cav2.1, CAV2.1, Ccha1a, EA2, FHM, HPCA, la, leaner, MHP, MHP1, nmf352, rbA-1, rkr, rocker, SCA6, si:ch211-237k17.1, tg, totteringProtein level used designations for CACNA1A
- calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
- voltage-dependent calcium ion channel alpha subunit
- ZfCav2.1
- BI
- RBA-I
- brain calcium channel 1
- brain calcium channel I
- brain class A
- calcium channel alpha 1A
- calcium channel, L type, alpha-1 polypeptide
- calcium channel, voltage-dependent, alpha 1A subunit
- voltage-dependent P/Q-type calcium channel subunit alpha-1A
- voltage-gated calcium channel subunit alpha Cav2.1
- P/Q-type calcium channel alpha1A subunit
- calcium channel, P/Q type, alpha 1A
- calcium channel, alpha 1A subunit
- voltage-gated calcium channel alpha 1A subunit
- calcium channel BI-1
- calcium channel BI-2
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