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BSCL2 产品

(Berardinelli-Seip Congenital Lipodystrophy 2 (Seipin) (BSCL2))

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This gene encodes the multi-pass transmembrane protein protein seipin. This protein localizes to the endoplasmic reticulum and may be important for lipid droplet morphology. Mutations in this gene have been associated with congenital generalized lipodystrophy type 2 or Berardinelli-Seip syndrome, a rare autosomal recessive disease characterized by a near absence of adipose tissue and severe insulin resistance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Naturally occurring read-through transcription occurs between this locus and the neighboring locus HNRNPUL2 (heterogeneous nuclear ribonucleoprotein U-like 2).[provided by RefSeq, Mar 2011].

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Featured BSCL2 Categories

BSCL2 抗体

High quality antibodies with extensive validation data.

BSCL2 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

BSCL2 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended BSCL2 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (2)
  • (3)
Cat. No. ABIN1327730
Quantity 50 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
  • (2)
Cat. No. ABIN525761
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IF
Validations
  • (3)
Cat. No. ABIN7265874
Quantity 100 μL
Datasheet Datasheet

Recommended BSCL2 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method
Validations
Cat. No. ABIN1156732
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1156733
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method
Validations
Cat. No. ABIN1156734
Quantity 96 tests
Datasheet Datasheet

Recommended BSCL2 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1346899
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1346897
Quantity 10 μg
Datasheet Datasheet
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3120374
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our BSCL2 Products

Liu, Jiang, Wang, Zhang, Lin, Lam, Shui, Zhou, Li, Wang, Cui, Gao, Zhang, Lv, Xu, Liu, Zhao, Yang: "Adipose-specific knockout of SEIPIN/BSCL2 results in progressive lipodystrophy." in: Diabetes, Vol. 63, Issue 7, pp. 2320-31, (2014) (PubMed).

Hölttä-Vuori, Salo, Ohsaki, Suster, Ikonen: "Alleviation of seipinopathy-related ER stress by triglyceride storage." in: Human molecular genetics, Vol. 22, Issue 6, pp. 1157-66, (2013) (PubMed).

Cui, Wang, Meng, Fei, Deng, Xu, Peng, Ju, Zhang, Liu, Zhao, Yang: "Overexpression of a short human seipin/BSCL2 isoform in mouse adipose tissue results in mild lipodystrophy." in: American journal of physiology. Endocrinology and metabolism, Vol. 302, Issue 6, pp. E705-13, (2012) (PubMed).

Synonyms and alternative names related to BSCL2

BSCL2, seipin lipid droplet biogenesis associated (BSCL2), BSCL2, seipin lipid droplet biogenesis associated (Bscl2), Berardinelli-Seip congenital lipodystrophy 2 (seipin) (Bscl2), 2900097C17Rik, AI046355, GNG3LG, Gng3lg, HMN5, SPG17

Protein level used designations for BSCL2

  • Bernardinelli-Seip congenital lipodystrophy type 2 protein
  • seipin
  • Bernardinelli-Seip congenital lipodystrophy 2 (seipin)
  • bernardinelli-Seip congenital lipodystrophy type 2 protein homolog
  • G protein gamma 3 linked
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