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BRSK1 产品

(BR Serine/threonine Kinase 1 (BRSK1))
Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Ser-573'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV- induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C (By similarity). In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1.

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Featured BRSK1 Categories

BRSK1 抗体

High quality antibodies with extensive validation data.

BRSK1 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

BRSK1 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended BRSK1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IHC
Validations
  • (3)
Cat. No. ABIN7169019
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Application WB
Validations
  • (3)
  • (1)
Cat. No. ABIN1881121
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IF, ICC
Validations
  • (2)
Cat. No. ABIN5066517
Quantity 100 μg
Datasheet Datasheet

Recommended BRSK1 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Rat
Analytical Method
Validations
Cat. No. ABIN1157191
Quantity 96 tests
Datasheet Datasheet
Reactivity Human, Mouse
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN5648007
Quantity 96 tests
Datasheet Datasheet

Recommended BRSK1 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1346887
Quantity 10 μg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
Cat. No. ABIN5509205
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3090446
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our BRSK1 Products

Zempel, Thies, Mandelkow, Mandelkow: "Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 36, pp. 11938-50, (2010) (PubMed).

Alvarado-Kristensson, Rodríguez, Silió, Valpuesta, Carrera: "SADB phosphorylation of gamma-tubulin regulates centrosome duplication." in: Nature cell biology, Vol. 11, Issue 9, pp. 1081-92, (2009) (PubMed).

Fogarty, Hardie: "C-terminal phosphorylation of LKB1 is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrest." in: The Journal of biological chemistry, Vol. 284, Issue 1, pp. 77-84, (2008) (PubMed).

Bright, Carling, Thornton: "Investigating the regulation of brain-specific kinases 1 and 2 by phosphorylation." in: The Journal of biological chemistry, Vol. 283, Issue 22, pp. 14946-54, (2008) (PubMed).

Kishi, Pan, Crump, Sanes: "Mammalian SAD kinases are required for neuronal polarization." in: Science (New York, N.Y.), Vol. 307, Issue 5711, pp. 929-32, (2005) (PubMed).

Lu, Niida, Nakanishi: "Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function." in: The Journal of biological chemistry, Vol. 279, Issue 30, pp. 31164-70, (2004) (PubMed).

Lizcano, Göransson, Toth, Deak, Morrice, Boudeau, Hawley, Udd, Mäkelä, Hardie, Alessi: "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1." in: The EMBO journal, Vol. 23, Issue 4, pp. 833-43, (2004) (PubMed).

Synonyms and alternative names related to BRSK1

BR serine/threonine kinase 1 (BRSK1), BR serine/threonine kinase 1 (Brsk1), BRSK1, Gm1100, hSAD1, RGD1563268, SAD-B, Sad-b, SADB

Protein level used designations for BRSK1

  • BR serine/threonine kinase 1
  • BR serine/threonine-protein kinase 1-like
  • BR serine/threonine-protein kinase 1
  • SAD1 homolog
  • SAD1 kinase
  • SadB kinase short isoform
  • brain-selective kinase 1
  • brain-specific serine/threonine-protein kinase 1
  • protein kinase SAD1A
  • serine/threonine-protein kinase BRSK1
  • serine/threonine-protein kinase SAD-B
  • synapses of Amphids Defective homolog 1
  • serine/threonine kinase SAD-B
  • serine/threonine kinase SADB
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