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BRD2 产品

(Bromodomain Containing 2 (BRD2))

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This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene. [provided by RefSeq, Dec 2010].

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Featured BRD2 Categories

BRD2 抗体

High quality antibodies with extensive validation data.

BRD2 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended BRD2 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, FACS
Validations
  • (5)
Cat. No. ABIN5542291
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (1)
  • (3)
Cat. No. ABIN562664
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC
Validations
  • (4)
Cat. No. ABIN7265939
Quantity 100 μL
Datasheet Datasheet

Recommended BRD2 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN428131
Quantity 96 tests
Datasheet Datasheet

Recommended BRD2 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7122047
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1346854
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7122048
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our BRD2 Products

Villain, Poissonnier, Noueihed, Bonfils, Rivera, Chemtob, Soncin, Mattot: "miR-126-5p promotes retinal endothelial cell survival through SetD5 regulation in neurons." in: Development (Cambridge, England), Vol. 145, Issue 1, (2018) (PubMed).

Surface, Fields, Subramanian, Behmer, Udeshi, Peach, Carr, Jaffe, Boyer: "H2A.Z.1 Monoubiquitylation Antagonizes BRD2 to Maintain Poised Chromatin in ESCs." in: Cell reports, Vol. 14, Issue 5, pp. 1142-55, (2016) (PubMed).

Asangani, Dommeti, Wang, Malik, Cieslik, Yang, Escara-Wilke, Wilder-Romans, Dhanireddy, Engelke, Iyer, Jing, Wu, Cao, Qin, Wang, Feng, Chinnaiyan: "Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer." in: Nature, Vol. 510, Issue 7504, pp. 278-82, (2014) (PubMed).

Lee, Lee, Jang, Chi, Kim, Li, Kim, Kim, Choi, Kim, Chung, Lee, Lee, Suh, Chuang, Ito, Bae: "Runx3 inactivation is a crucial early event in the development of lung adenocarcinoma." in: Cancer cell, Vol. 24, Issue 5, pp. 603-16, (2013) (PubMed).

Pal, Evgrafov, Tabares, Zhang, Durner, Greenberg: "BRD2 (RING3) is a probable major susceptibility gene for common juvenile myoclonic epilepsy." in: American journal of human genetics, Vol. 73, Issue 2, pp. 261-70, (2003) (PubMed).

Crowley, Kaine, Yoshida, Nandi, Wolgemuth: "Reproductive cycle regulation of nuclear import, euchromatic localization, and association with components of Pol II mediator of a mammalian double-bromodomain protein." in: Molecular endocrinology (Baltimore, Md.), Vol. 16, Issue 8, pp. 1727-37, (2002) (PubMed).

Denis, Vaziri, Guo, Faller: "RING3 kinase transactivates promoters of cell cycle regulatory genes through E2F." in: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, Vol. 11, Issue 8, pp. 417-24, (2000) (PubMed).

Synonyms and alternative names related to BRD2

Ring3 protein (CHLREDRAFT_190116), Ring3 protein (CHLREDRAFT_150233), Ring3 protein (CHLREDRAFT_182576), Ring3 protein (CHLREDRAFT_188250), bromodomain containing 2 (BRD2), bromodomain containing 2 (Brd2), bromodomain containing 2 S homeolog (brd2.S), bromodomain containing 2a (brd2a), AW228947, brd2, brd2-a, D6S113E, D17H6S113E, fe47f02, fi85h05, Frg-1, FSH, fsh, Fsrg-1, FSRG1, Fsrg1, fsrg1, mKIAA4005, NAT, Nat, nat, RING3, Ring3, ring3, RNF3, Rnf3, rnf3, wu:fe47f02, wu:fi85h05

Protein level used designations for BRD2

  • Ring3 protein
  • O27.1.1
  • bromodomain-containing 2
  • bromodomain-containing protein 2
  • female sterile homeotic-related gene 1
  • really interesting new gene 3 protein
  • collagen type XI alpha 2
  • glutamate-cysteine ligase catalytic subunit
  • ring finger protein 3
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