BRCA1 抗体
(Breast Cancer 1 (BRCA1))
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009].
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Reactivity
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Validations
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Datasheet
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Application
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Cat. No.
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Quantity
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Datasheet
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Application
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Cat. No.
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Quantity
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Cat. No.
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Cat. No.
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Quantity
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Datasheet
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Cat. No.
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Cat. No.
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Cat. No.
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Cat. No.
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Reactivity
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Cat. No.
ABIN682903
Quantity
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Datasheet
Datasheet
Reactivity
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Application
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Validations
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Cat. No.
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Quantity
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Datasheet
Datasheet
Reactivity
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Application
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Validations
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Cat. No.
ABIN7442471
Quantity
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Datasheet
Datasheet
Reactivity
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Datasheet
Datasheet
Latest Publications for our BRCA1 抗体
: "Single-dose radiotherapy disables tumor cell homologous recombination via ischemia/reperfusion injury. ..." in: The Journal of clinical investigation, Vol. 129, Issue 2, pp. 786-801, (2019) (PubMed).: "PARP inhibitor veliparib and HDAC inhibitor SAHA synergistically co-target the UHRF1/BRCA1 DNA damage repair complex in prostate cancer cells." in: Journal of experimental & clinical cancer research : CR, Vol. 37, Issue 1, pp. 153, (2018) (PubMed).
: "Therapeutic Impact of Nanoparticle Therapy Targeting Tumor-Associated Macrophages." in: Molecular cancer therapeutics, Vol. 17, Issue 1, pp. 96-106, (2018) (PubMed).
: "Dianhydrogalactitol induces replication-dependent DNA damage in tumor cells preferentially resolved by homologous recombination." in: Cell death & disease, Vol. 9, Issue 10, pp. 1016, (2018) (PubMed).
: "Di (2-ethylhexyl) phthalate exposure impairs meiotic progression and DNA damage repair in fetal mouse oocytes in vitro." in: Cell death & disease, Vol. 8, Issue 8, pp. e2966, (2017) (PubMed).
: "Artemisinin mimics calorie restriction to trigger mitochondrial biogenesis and compromise telomere shortening in mice." in: PeerJ, Vol. 3, pp. e822, (2015) (PubMed).
: "Characterization of the platelet-derived growth factor receptor-α-positive cell lineage during murine late lung development." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 309, Issue 9, pp. L942-58, (2015) (PubMed).
: "Homozygous mutation of MTPAP causes cellular radiosensitivity and persistent DNA double-strand breaks." in: Cell death & disease, Vol. 5, pp. e1130, (2014) (PubMed).
: "Quantitative measurement of alterations in DNA damage repair (DDR) pathways using single cell network profiling (SCNP)." in: Journal of translational medicine, Vol. 12, pp. 184, (2014) (PubMed).
: "Validation of the BRCA1 antibody MS110 and the utility of BRCA1 as a patient selection biomarker in immunohistochemical analysis of breast and ovarian tumours." in: Virchows Archiv : an international journal of pathology, Vol. 462, Issue 3, pp. 269-79, (2013) (PubMed).
Aliases for BRCA1 抗体
BRCA1, DNA repair associated (BRCA1) 抗体breast cancer 1 (brca1) 抗体
breast cancer 1, early onset (LOC755086) 抗体
breast cancer 1, early onset (Brca1) 抗体
BRCA1, DNA repair associated (Brca1) 抗体
breast cancer 1, early onset (BRCA1) 抗体
breast cancer 1 L homeolog (brca1.L) 抗体
brca1 抗体
BRCA1 抗体
BRCAI 抗体
brcai 抗体
BRCC1 抗体
brcc1 抗体
BROVCA1 抗体
IRIS 抗体
iris 抗体
LOC100224649 抗体
PNCA4 抗体
PPP1R53 抗体
PSCP 抗体
pscp 抗体
RNF53 抗体
rnf53 抗体
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