BIN1 产品
(Bridging Integrator 1 (BIN1))
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This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. [provided by RefSeq, Sep 2011].
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Featured BIN1 Categories
BIN1 抗体
High quality antibodies with extensive validation data.
BIN1 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
BIN1 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended BIN1 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Rat
Application
WB, IHC, IF
Validations
- (5)
Cat. No.
ABIN7259755
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (5)
Cat. No.
ABIN1678863
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF, ICC, IHC (p)
Validations
- (1)
- (4)
Cat. No.
ABIN2855595
Quantity
100 μL
Datasheet
Datasheet
Recommended BIN1 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6954195
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6201968
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6201967
Quantity
96 tests
Datasheet
Datasheet
Recommended BIN1 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
- (1)
Cat. No.
ABIN2715270
Quantity
20 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN667182
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1346681
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our BIN1 Products
: "Adverse transverse-tubule remodeling in a rat model of heart failure is attenuated with low-dose triiodothyronine treatment." in: Molecular medicine (Cambridge, Mass.), Vol. 25, Issue 1, pp. 53, (2020) (PubMed).: "FBP17 and CIP4 recruit SHIP2 and lamellipodin to prime the plasma membrane for fast endophilin-mediated endocytosis." in: Nature cell biology, Vol. 20, Issue 9, pp. 1023-1031, (2019) (PubMed).
: "Tau phosphorylation regulates the interaction between BIN1's SH3 domain and Tau's proline-rich domain." in: Acta neuropathologica communications, Vol. 3, pp. 58, (2015) (PubMed).
: "Bridging integrator 1 (BIN1) protein expression increases in the Alzheimer's disease brain and correlates with neurofibrillary tangle pathology." in: Journal of Alzheimer's disease : JAD, Vol. 42, Issue 4, pp. 1221-7, (2014) (PubMed).
: "Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells." in: Nature methods, Vol. 10, Issue 4, pp. 315-23, (2013) (PubMed).
: "Mutations in amphiphysin 2 (BIN1) disrupt interaction with dynamin 2 and cause autosomal recessive centronuclear myopathy." in: Nature genetics, Vol. 39, Issue 9, pp. 1134-9, (2007) (PubMed).
: "Bin1 attenuation in breast cancer is correlated to nodal metastasis and reduced survival." in: Cancer biology & therapy, Vol. 6, Issue 2, pp. 192-4, (2007) (PubMed).
: "Human T-cell lymphotrophic virus type I rex and p30 interactions govern the switch between virus latency and replication." in: The Journal of biological chemistry, Vol. 282, Issue 19, pp. 14608-15, (2007) (PubMed).
: "A role for the putative tumor suppressor Bin1 in muscle cell differentiation." in: Molecular and cellular biology, Vol. 18, Issue 1, pp. 566-75, (1998) (PubMed).
: "Structural analysis of the human BIN1 gene. Evidence for tissue-specific transcriptional regulation and alternate RNA splicing." in: The Journal of biological chemistry, Vol. 272, Issue 50, pp. 31453-8, (1998) (PubMed).
Synonyms and alternative names related to BIN1
bridging integrator 1 (BIN1), bridging integrator 1 S homeolog (bin1.S), bridging integrator 1 (bin1), bridging integrator 1b (bin1b), bridging integrator 1 (Bin1), ALP-1, amph2, AMPH2, amphl, AMPHL, Amphl, bin1, BIN1, BRAMP-2, cb57, MGC53185, MGC76187, sh3p9, SH3P9, zgc:86701Protein level used designations for BIN1
- bridging integrator 1
- myc box-dependent-interacting protein 1-like
- amphiphysin II
- amphiphysin-like protein
- box dependant MYC interacting protein 1
- box-dependent myc-interacting protein 1
- myc box-dependent-interacting protein 1
- SH3 domain-containing protein 9
- amphiphysin 2
- myc box dependent interacting protein 1
- Amph2
- amphiphysin IIamph2
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