BCL11A 产品
(B-Cell CLL/lymphoma 11A (Zinc Finger Protein) (BCL11A))
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This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Featured BCL11A Categories
BCL11A 抗体
High quality antibodies with extensive validation data.
BCL11A ELISA试剂盒
Reliable ELISA kits for a wide range of species.
BCL11A 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended BCL11A 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p), IF
Validations
- (5)
Cat. No.
ABIN526947
Quantity
100 μg
Datasheet
Datasheet
Application
WB, IHC, IHC (p)
Validations
- (4)
Cat. No.
ABIN6741578
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7145171
Quantity
100 μL
Datasheet
Datasheet
Recommended BCL11A ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6954027
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN1123168
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6223083
Quantity
96 tests
Datasheet
Datasheet
Recommended BCL11A 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1346538
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1346540
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7407040
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our BCL11A Products
: "A natural regulatory mutation in the proximal promoter elevates fetal globin expression by creating a de novo GATA1 site." in: Blood, Vol. 133, Issue 8, pp. 852-856, (2019) (PubMed).: "Natural regulatory mutations elevate the fetal globin gene via disruption of BCL11A or ZBTB7A binding." in: Nature genetics, Vol. 50, Issue 4, pp. 498-503, (2018) (PubMed).
: "Bcl11a controls Flt3 expression in early hematopoietic progenitors and is required for pDC development in vivo." in: PLoS ONE, Vol. 8, Issue 5, pp. e64800, (2013) (PubMed).
: "Transcriptional silencing of {gamma}-globin by BCL11A involves long-range interactions and cooperation with SOX6." in: Genes & development, Vol. 24, Issue 8, pp. 783-98, (2010) (PubMed).
: "BCL11A represses HBG transcription in K562 cells." in: Blood cells, molecules & diseases, Vol. 42, Issue 2, pp. 144-9, (2009) (PubMed).
: "Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 5, pp. 1620-5, (2008) (PubMed).
: "Novel markers of normal and neoplastic human plasmacytoid dendritic cells." in: Blood, Vol. 111, Issue 7, pp. 3778-92, (2008) (PubMed).
: "Functional studies of BCL11A: characterization of the conserved BCL11A-XL splice variant and its interaction with BCL6 in nuclear paraspeckles of germinal center B cells." in: Molecular cancer, Vol. 5, pp. 18, (2006) (PubMed).
: "The BCL11AXL transcription factor: its distribution in normal and malignant tissues and use as a marker for plasmacytoid dendritic cells." in: Leukemia, Vol. 20, Issue 8, pp. 1439-41, (2006) (PubMed).
: "Hydroxyurea differentially modulates activator and repressors of γ-globin gene in erythroblasts of responsive and non-responsive patients with sickle cell disease in correlation with Index of ..." in: Haematologica, Vol. 102, Issue 12, pp. 1995-2004 (PubMed).
Synonyms and alternative names related to BCL11A
B cell CLL/lymphoma 11A (zinc finger protein) (Bcl11a), B-cell CLL/lymphoma 11A (BCL11A), B-cell CLL/lymphoma 11A L homeolog (bcl11a.L), B-cell CLL/lymphoma 11A (Bcl11a), B-cell CLL/lymphoma 11Aa (bcl11aa), 2810047E18Rik, BCL-11A, bcl11a, BCL11A-L, BCL11a-M, BCL11A-S, BCL11A-XL, Ctip1, CTIP1, D930021L15Rik, Evi9, EVI9, Evi9a, Evi9b, Evi9c, HBFQTL5, mKIAA1809, wu:fi09f10, zgc:136898, ZNF856Protein level used designations for BCL11A
- B-cell CLL/lymphoma 11A (zinc finger protein)
- B-cell lymphoma/leukemia 11A
- COUP-TF interacting protein 1
- COUP-TF-interacting protein 1
- EVI-9
- ecotropic viral integration site 9 protein
- myeloid leukemia
- B-cell CLL/lymphoma 11A (zinc finger protein) isoform 2
- BCL-11A
- BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) isoform 1
- C2H2-type zinc finger protein
- ecotropic viral integration site 9 homolog
- ecotropic viral integration site 9 protein homolog
- zinc finger protein 856
- B-cell CLL/lymphoma 11A
- bcl11a.1
- fi09f10
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