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BCCIP 产品

(BRCA2 and CDKN1A Interacting Protein (BCCIP))
This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].

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Featured BCCIP Categories

BCCIP 抗体

High quality antibodies with extensive validation data.

BCCIP ELISA试剂盒

Reliable ELISA kits for a wide range of species.

BCCIP 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended BCCIP 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC
Validations
  • (4)
Cat. No. ABIN6137485
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF, IHC (p), ICC
Validations
  • (4)
Cat. No. ABIN2856892
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
  • (3)
Cat. No. ABIN527937
Quantity 50 μg
Datasheet Datasheet

Recommended BCCIP ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1124123
Quantity 96 tests
Datasheet Datasheet
Reactivity Cow
Analytical Method
Validations
Cat. No. ABIN1124121
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6730078
Quantity 96 tests
Datasheet Datasheet

Recommended BCCIP 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7122031
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1346518
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1346520
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our BCCIP Products

Lu, Guo, Meng, Liu, Allen, Wray, Nickoloff, Shen: "The BRCA2-interacting protein BCCIP functions in RAD51 and BRCA2 focus formation and homologous recombinational repair." in: Molecular and cellular biology, Vol. 25, Issue 5, pp. 1949-57, (2005) (PubMed).

Meng, Liu, Shen: "Inhibition of G1 to S cell cycle progression by BCCIP beta." in: Cell cycle (Georgetown, Tex.), Vol. 3, Issue 3, pp. 343-8, (2004) (PubMed).

Robson, Scheuer, Nafa, Ellis, Offit: "Unique de novo mutation of BRCA2 in a woman with early onset breast cancer." in: Journal of medical genetics, Vol. 39, Issue 2, pp. 126-8, (2002) (PubMed).

Liu, Yuan, Huan, Shen: "Inhibition of breast and brain cancer cell growth by BCCIPalpha, an evolutionarily conserved nuclear protein that interacts with BRCA2." in: Oncogene, Vol. 20, Issue 3, pp. 336-45, (2001) (PubMed).

Ono, Kitaura, Ugai, Murata, Yokoyama, Iguchi-Ariga, Ariga: "TOK-1, a novel p21Cip1-binding protein that cooperatively enhances p21-dependent inhibitory activity toward CDK2 kinase." in: The Journal of biological chemistry, Vol. 275, Issue 40, pp. 31145-54, (2000) (PubMed).

Synonyms and alternative names related to BCCIP

BRCA2 and CDKN1A interacting protein (BCCIP), BRCA2 and CDKN1A interacting protein (bccip), BRCA2 and CDKN1A interacting protein L homeolog (bccip.L), BRCA2 and CDKN1A interacting protein (Bccip), 1110013J05Rik, BCCIP, DKFZp459K2416, MGC82792, MGC89311, mp:zf637-1-000774, tok-1, TOK-1, TOK1, zgc:110272

Protein level used designations for BCCIP

  • BRCA2 and CDKN1A interacting protein
  • protein BCCIP homolog
  • BRCA2 and CDKN1A-interacting protein
  • bccip-like
  • BCCIPalpha
  • BCCIPbeta
  • BRCA2 and Cip1/p21 interacting protein
  • TOK-1alpha
  • TOK-1beta
  • cdk inhibitor p21 binding protein
  • p21- and CDK-associated protein 1
  • protein TOK-1
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