B-Cell Linker 产品
(B-Cell Linker (BLNK))
Categories
This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012].
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Featured B-Cell Linker Categories
B-Cell Linker 抗体
High quality antibodies with extensive validation data.
B-Cell Linker ELISA试剂盒
Reliable ELISA kits for a wide range of species.
B-Cell Linker 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended B-Cell Linker 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, FACS, ICC
Validations
- (2)
- (6)
Cat. No.
ABIN968984
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, ICC, IP
Validations
- (6)
Cat. No.
ABIN7441781
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, PLA
Validations
- (4)
Cat. No.
ABIN526104
Quantity
100 μg
Datasheet
Datasheet
Recommended B-Cell Linker ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Pig
Analytical Method
Quantitative
Validations
Cat. No.
ABIN778228
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rabbit
Analytical Method
Quantitative Competition ELISA
Validations
Cat. No.
ABIN774331
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Competition ELISA
Validations
Cat. No.
ABIN771530
Quantity
96 tests
Datasheet
Datasheet
Recommended B-Cell Linker 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1346719
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1346721
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7121966
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our B-Cell Linker Products
: "Expression of the B-cell receptor component CD79a on immature myeloid cells contributes to their tumor promoting effects." in: PLoS ONE, Vol. 8, Issue 10, pp. e76115, (2013) (PubMed).: "Phospho-proteomic analysis of mantle cell lymphoma cells suggests a pro-survival role of B-cell receptor signaling." in: Cellular oncology (Dordrecht), Vol. 34, Issue 2, pp. 141-53, (2011) (PubMed).
: "BLNK binds active H-Ras to promote B cell receptor-mediated capping and ERK activation." in: The Journal of biological chemistry, Vol. 284, Issue 15, pp. 9804-13, (2009) (PubMed).
: "Impaired B-cell development at the pre-BII-cell stage in galectin-1-deficient mice due to inefficient pre-BII/stromal cell interactions." in: Blood, Vol. 113, Issue 23, pp. 5878-86, (2009) (PubMed).
: "B-cell linker protein prevents aneuploidy by inhibiting cytokinesis." in: Cancer science, Vol. 99, Issue 12, pp. 2444-54, (2008) (PubMed).
: "SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond." in: Nature reviews. Immunology, Vol. 6, Issue 1, pp. 67-78, (2006) (PubMed).
: "The SLP-76 family of adapter proteins." in: Seminars in immunology, Vol. 16, Issue 6, pp. 379-93, (2004) (PubMed).
: "Deficiency of BLNK hampers PLC-gamma2 phosphorylation and Ca2+ influx induced by the pre-B-cell receptor in human pre-B cells." in: Immunology, Vol. 112, Issue 4, pp. 575-82, (2004) (PubMed).
: "Adaptor proteins in lymphocyte activation." in: Current opinion in immunology, Vol. 15, Issue 3, pp. 269-76, (2003) (PubMed).
: "Bruton's tyrosine kinase cooperates with the B cell linker protein SLP-65 as a tumor suppressor in Pre-B cells." in: The Journal of experimental medicine, Vol. 198, Issue 1, pp. 91-8, (2003) (PubMed).
Synonyms and alternative names related to B-Cell Linker
B-cell linker (BLNK), B-cell linker (blnk), B cell linker (Blnk), B-cell linker (Blnk), AGM4, BASH, Bca, bca, BLNK, blnk, BLNK-S, Ly-57, Ly57, LY57, Lyw-57, MGC147045, SLP-65, SLP65Protein level used designations for B-Cell Linker
- B-cell linker
- B-cell linker protein
- b-cell linker protein-like
- B-cell adapter containing a SH2 domain protein
- B-cell adapter containing a Src homology 2 domain protein
- cytoplasmic adapter protein
- lymphocyte antigen 57
- src homology 2 domain-containing leukocyte protein of 65 kDa
- B cell adaptor containing SH2 domain
- B cell linker protein
- B-cell activation
- Src homology 2 domain-containing leukocyte protein of 65 kDa
- Src homology [SH2] domain-containing leukocyte protein of 65 kD
- B cell linker protein BLNK
- B-cell adapter SH2 domain-containing protein
- SLP-65
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