BARD1 产品
(BRCA1 Associated RING Domain 1 (BARD1))
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This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer. [provided by RefSeq, Jul 2008].
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Featured BARD1 Categories
BARD1 抗体
High quality antibodies with extensive validation data.
BARD1 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
BARD1 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended BARD1 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
- (1)
- (1)
Cat. No.
ABIN706496
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IF
Validations
- (2)
Cat. No.
ABIN560033
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (1)
Cat. No.
ABIN7188551
Quantity
100 μg
Datasheet
Datasheet
Recommended BARD1 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Validations
Cat. No.
ABIN1124118
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN1124119
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Validations
Cat. No.
ABIN1124120
Quantity
96 tests
Datasheet
Datasheet
Recommended BARD1 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1346405
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3089922
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3132003
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our BARD1 Products
: "FOXK2 transcription factor suppresses ER?-positive breast cancer cell growth through down-regulating the stability of ER? via mechanism involving BRCA1/BARD1." in: Scientific reports, Vol. 5, pp. 8796, (2015) (PubMed).: "The BARD1 BRCT domain contributes to p53 binding, cytoplasmic and mitochondrial localization, and apoptotic function." in: Cellular signalling, Vol. 27, Issue 9, pp. 1763-71, (2015) (PubMed).
: "Prognostic and biological significance of proliferation and HER2 expression in the luminal class of breast cancer." in: Breast cancer research and treatment, Vol. 145, Issue 2, pp. 317-30, (2014) (PubMed).
: "SUMOylation proteins in breast cancer." in: Breast cancer research and treatment, Vol. 144, Issue 3, pp. 519-30, (2014) (PubMed).
: "Common variation at BARD1 results in the expression of an oncogenic isoform that influences neuroblastoma susceptibility and oncogenicity. ..." in: Cancer research, Vol. 72, Issue 8, pp. 2068-78, (2012) (PubMed).
: "The in vivo dynamic organization of BRCA1-A complex proteins at DNA damage-induced nuclear foci." in: Traffic (Copenhagen, Denmark), Vol. 13, Issue 6, pp. 800-14, (2012) (PubMed).
: "Expression of oncogenic BARD1 isoforms affects colon cancer progression and correlates with clinical outcome." in: British journal of cancer, Vol. 107, Issue 4, pp. 675-83, (2012) (PubMed).
: "BRCA1-associated exclusion of 53BP1 from DNA damage sites underlies temporal control of DNA repair." in: Journal of cell science, Vol. 125, Issue Pt 15, pp. 3529-34, (2012) (PubMed).
: "HERC2 is an E3 ligase that targets BRCA1 for degradation." in: Cancer research, Vol. 70, Issue 15, pp. 6384-92, (2010) (PubMed).
: "Transcriptional autoregulation by BRCA1." in: Cancer research, Vol. 70, Issue 2, pp. 532-42, (2010) (PubMed).
Synonyms and alternative names related to BARD1
BRCA1 associated RING domain 1 (BARD1), BRCA1 associated RING domain 1 (bard1), BRCA1 associated RING domain 1 (Bard1), BARD1, ENSMUSG00000060893, ENSMUSG00000073653, LOC100147913Protein level used designations for BARD1
- BRCA1 associated RING domain 1
- BRCA1-associated RING domain protein 1-like
- BRCA1 associated RING domain 1 isoform alfa
- BRCA1 associated RING domain 1 isoform beta
- BRCA1 associated RING domain 1 isoform delta
- BRCA1 associated RING domain 1 isoform epsilon
- BRCA1 associated RING domain 1 isoform eta
- BRCA1 associated RING domain 1 isoform gamma
- BRCA1 associated RING domain 1 isoform phi
- BRCA1-associated RING domain gene 1
- BRCA1-associated RING domain protein 1
- BARD-1
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