BACE2 产品
(beta-Site APP-Cleaving Enzyme 2 (BACE2))
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Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by this gene. This gene localizes to the 'Down critical region' of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease. Three transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
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Featured BACE2 Categories
BACE2 抗体
High quality antibodies with extensive validation data.
BACE2 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
BACE2 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended BACE2 抗体
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ABIN7434101
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Recommended BACE2 ELISA试剂盒
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ABIN6965163
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Recommended BACE2 蛋白
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Latest Publications for our BACE2 Products
: "BACE-2 is overexpressed in Down's syndrome." in: Experimental neurology, Vol. 182, Issue 2, pp. 335-45, (2003) (PubMed).: "Antagonistic effects of beta-site amyloid precursor protein-cleaving enzymes 1 and 2 on beta-amyloid peptide production in cells." in: The Journal of biological chemistry, Vol. 278, Issue 34, pp. 31512-20, (2003) (PubMed).
: "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. ..." in: Genome research, Vol. 13, Issue 10, pp. 2265-70, (2003) (PubMed).
: "The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the down critical region." in: FEBS letters, Vol. 468, Issue 1, pp. 59-64, (2000) (PubMed).
: "Expression analysis of BACE2 in brain and peripheral tissues." in: The Journal of biological chemistry, Vol. 275, Issue 27, pp. 20647-51, (2000) (PubMed).
: "BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 17, pp. 9712-7, (2000) (PubMed).
: "Expression of a murine homologue of the inhibitor of apoptosis protein is related to cell proliferation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 4, pp. 1457-62, (1999) (PubMed).
: "Control of apoptosis and mitotic spindle checkpoint by survivin." in: Nature, Vol. 396, Issue 6711, pp. 580-4, (1999) (PubMed).
: "A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma." in: Nature medicine, Vol. 3, Issue 8, pp. 917-21, (1997) (PubMed).
Synonyms and alternative names related to BACE2
beta-site APP-cleaving enzyme 2 (BACE2), beta-site APP-cleaving enzyme 2 (Bace2), 1110059C24Rik, AEPLC, AI850424, ALP56, ARP1, ASP1, ASP21, BAE2, CDA13, CEAP1, DRAPProtein level used designations for BACE2
- 56 kDa aspartic-like protease
- Down syndrome region aspartic protease
- aspartyl protease 1
- beta-secretase 2
- beta-site amyloid beta A4 precursor protein-cleaving enzyme 2
- memapsin-1
- membrane-associated aspartic protease 1
- theta-secretase
- transmembrane aspartic proteinase Asp1
- ASP1
- asp 1
- beta-site APP cleaving enzyme 2
- beta-site amyloid precursor protein cleaving enzyme 2
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