Axin 产品
(Axin 1 (AXIN1))
Categories
This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2010].
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Featured Axin Categories
Axin 抗体
High quality antibodies with extensive validation data.
Axin ELISA试剂盒
Reliable ELISA kits for a wide range of species.
Axin 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Axin 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, ICC, FACS, Neut
Validations
- (5)
Cat. No.
ABIN5611198
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Rat
Application
WB, IHC, IP, ICC
Validations
- (4)
Cat. No.
ABIN7442327
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF, PLA
Validations
- (4)
Cat. No.
ABIN563582
Quantity
100 μg
Datasheet
Datasheet
Recommended Axin ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6965097
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Competition ELISA
Validations
Cat. No.
ABIN512400
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Pig
Analytical Method
Quantitative
Validations
Cat. No.
ABIN777945
Quantity
96 tests
Datasheet
Datasheet
Recommended Axin 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7121954
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1346237
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
- (1)
Cat. No.
ABIN2715088
Quantity
20 μg
Datasheet
Datasheet
Latest Publications for our Axin Products
: "Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation." in: Nature chemical biology, Vol. 12, Issue 8, pp. 593-600, (2016) (PubMed).: "AHSA1 regulates proliferation, apoptosis, migration, and invasion of osteosarcoma." in: Biomedicine & pharmacotherapy, Vol. 77, pp. 45-51, (2016) (PubMed).
: "Human Sarcoma growth is sensitive to small-molecule mediated AXIN stabilization." in: PLoS ONE, Vol. 9, Issue 5, pp. e97847, (2014) (PubMed).
: "Identification and characterization of a small-molecule inhibitor of Wnt signaling in glioblastoma cells. ..." in: Molecular cancer therapeutics, Vol. 12, Issue 7, pp. 1180-9, (2013) (PubMed).
: "Differential stability of beta-catenin along the animal-vegetal axis of the sea urchin embryo mediated by dishevelled." in: Development (Cambridge, England), Vol. 131, Issue 12, pp. 2947-56, (2004) (PubMed).
: "The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation." in: Cell, Vol. 90, Issue 1, pp. 181-92, (1997) (PubMed).
Synonyms and alternative names related to Axin
axin 1 (AXIN1), axin 1 S homeolog (axin1.S), axin 1 L homeolog (axin1.L), axin 1 (Axin1), axin 1 (axin1), AI316800, axin, AXIN, Axin, AXIN1, AXIN1-RGS, Fu, fused, Kb, Ki, kinky, knobbly, LOC100226467, PPP1R49, wu:fi22e03, wu:fj14c08, wu:fk11b03, xAxin, zgc:109872Protein level used designations for Axin
- axin 1
- axin 1, isoform 1
- axin-1-like
- axin-1
- xAxin
- axis inhibition protein 1
- axis inhibitor 1
- fused, mouse, homolog of
- protein phosphatase 1, regulatory subunit 49
- protein Fused
- GSK-3beta interacting protein rAxin
- rAxin
- masterblind
- mbl
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