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AVPR2 产品

(Arginine Vasopressin Receptor 2 (AVPR2))
This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these 'extrarenal receptors' are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. The gene expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing. [provided by RefSeq, Jul 2008].

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Featured AVPR2 Categories

AVPR2 抗体

High quality antibodies with extensive validation data.

AVPR2 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

AVPR2 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended AVPR2 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Cow, Dog, Guinea Pig, Human, Monkey, Sheep
Application WB, IHC, IHC (p)
Validations
  • (1)
  • (3)
Cat. No. ABIN1492332
Quantity 50 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IF, IHC
Validations
  • (3)
Cat. No. ABIN7175412
Quantity 100 μg
Datasheet Datasheet
Reactivity Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep
Application WB
Validations
  • (4)
Cat. No. ABIN2788110
Quantity 100 μL
Datasheet Datasheet

Recommended AVPR2 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6953923
Quantity 96 tests
Datasheet Datasheet

Recommended AVPR2 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7413085
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Mammalian Cells
Validations
Cat. No. ABIN7538139
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3097306
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our AVPR2 Products

Sakai, Yamazaki, Ishizawa, Tamura, Wang, Ueno, Hayama, Fujigaki, Shibata: "Upregulation of renal Na-K-2Cl cotransporter 2 in obese diabetes mellitus via a vasopressin receptor 2-dependent pathway." in: Biochemical and biophysical research communications, Vol. 524, Issue 3, pp. 710-715, (2020) (PubMed).

Zhang, Lin, Zhao, Guo, Yan, Lin: "Revealing the Effects of the Herbal Pair of Euphorbia kansui and Glycyrrhiza on Hepatocellular Carcinoma Ascites with Integrating Network Target Analysis and Experimental Validation." in: International journal of biological sciences, Vol. 12, Issue 5, pp. 594-606, (2017) (PubMed).

Canal, Wilkinson, Cooper, Wraith, Wynn, Bigger: "Circadian rhythm and suprachiasmatic nucleus alterations in the mouse model of mucopolysaccharidosis IIIB." in: Behavioural brain research, Vol. 209, Issue 2, pp. 212-20, (2010) (PubMed).

Mutig, Paliege, Kahl, Jöns, Müller-Esterl, Bachmann: "Vasopressin V2 receptor expression along rat, mouse, and human renal epithelia with focus on TAL." in: American journal of physiology. Renal physiology, Vol. 293, Issue 4, pp. F1166-77, (2007) (PubMed).

North, Fay, Longo, Du: "Expression of all known vasopressin receptor subtypes by small cell tumors implies a multifaceted role for this neuropeptide." in: Cancer research, Vol. 58, Issue 9, pp. 1866-71, (1998) (PubMed).

Fay, Du, Yu, North: "Evidence for expression of vasopressin V2 receptor mRNA in human lung." in: Peptides, Vol. 17, Issue 3, pp. 477-81, (1996) (PubMed).

Wildin, Antush, Bennett, Schoof, Scott: "Heterogeneous AVPR2 gene mutations in congenital nephrogenic diabetes insipidus." in: American journal of human genetics, Vol. 55, Issue 2, pp. 266-77, (1994) (PubMed).

Seibold, Brabet, Rosenthal, Birnbaumer: "Structure and chromosomal localization of the human antidiuretic hormone receptor gene." in: American journal of human genetics, Vol. 51, Issue 5, pp. 1078-83, (1992) (PubMed).

Birnbaumer, Seibold, Gilbert, Ishido, Barberis, Antaramian, Brabet, Rosenthal: "Molecular cloning of the receptor for human antidiuretic hormone." in: Nature, Vol. 357, Issue 6376, pp. 333-5, (1992) (PubMed).

Synonyms and alternative names related to AVPR2

arginine vasopressin receptor 2 (AVPR2), arginine vasopressin receptor 2 (Avpr2), ADHR, AVPR2, DI1, DIR, DIR3, ND1, NDI, V2R, VPV2R

Protein level used designations for AVPR2

  • vasopressin V2 receptor
  • arginine vasopressin receptor 2
  • AVPR V2
  • antidiuretic hormone receptor
  • renal-type arginine vasopressin receptor
  • V-2 lysine vasopressin receptor
  • V2R
  • arginine vasopressin receptor 2 (nephrogenic diabetes insipidus)
  • nephrogenic diabetes insipidus
  • Vasopressin receptor V2
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