ATR 产品
(ATR serine/threonine kinase (ATR))
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The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist. [provided by RefSeq, Jul 2008].
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Featured ATR Categories
ATR 抗体
High quality antibodies with extensive validation data.
ATR ELISA试剂盒
Reliable ELISA kits for a wide range of species.
ATR 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended ATR 抗体
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Reactivity
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Reactivity
Human
Application
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Cat. No.
ABIN7265777
Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
ELISA, WB, FACS
Validations
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Cat. No.
ABIN7193431
Quantity
100 μL
Datasheet
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Cat. No.
ABIN560011
Quantity
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Datasheet
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Recommended ATR ELISA试剂盒
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Cat. No.
ABIN5526736
Quantity
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Cat. No.
ABIN5526737
Quantity
96 tests
Datasheet
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Reactivity
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Recommended ATR 蛋白
Latest Publications for our ATR Products
: "ZFP161 regulates replication fork stability and maintenance of genomic stability by recruiting the ATR/ATRIP complex." in: Nature communications, Vol. 10, Issue 1, pp. 5304, (2019) (PubMed).: "A type I IFN-dependent DNA damage response regulates the genetic program and inflammasome activation in macrophages." in: eLife, Vol. 6, (2017) (PubMed).
: "Poly(ADP-ribose) binding to Chk1 at stalled replication forks is required for S-phase checkpoint activation." in: Nature communications, Vol. 4, pp. 2993, (2013) (PubMed).
: "Constitutive turnover of phosphorylation at Thr-412 of human p57/coronin-1 regulates the interaction with actin." in: The Journal of biological chemistry, Vol. 287, Issue 51, pp. 42910-20, (2012) (PubMed).
: "Dysregulation of IRP1-mediated iron metabolism causes gamma ray-specific radioresistance in leukemia cells." in: PLoS ONE, Vol. 7, Issue 11, pp. e48841, (2012) (PubMed).
: "Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR." in: Cell cycle (Georgetown, Tex.), Vol. 10, Issue 4, pp. 655-63, (2011) (PubMed).
: "Hsp90 inhibitor-mediated disruption of chaperone association of ATR with hsp90 sensitizes cancer cells to DNA damage." in: Molecular cancer therapeutics, Vol. 10, Issue 7, pp. 1194-206, (2011) (PubMed).
: "ATR suppresses telomere fragility and recombination but is dispensable for elongation of short telomeres by telomerase." in: The Journal of cell biology, Vol. 188, Issue 5, pp. 639-52, (2010) (PubMed).
: "ATM- and ATR-mediated response to DNA damage induced by a novel camptothecin, ST1968." in: Cancer letters, Vol. 292, Issue 2, pp. 186-96, (2010) (PubMed).
: "Multiple DNA damage signaling and repair pathways deregulated by simian virus 40 large T antigen." in: Journal of virology, Vol. 84, Issue 16, pp. 8007-20, (2010) (PubMed).
Synonyms and alternative names related to ATR
ATR serine/threonine kinase (ATR), ataxia telangiectasia and Rad3 related (ATR), ataxia telangiectasia and Rad3 related (Atr), ATR serine/threonine kinase (Atr), FCTCS, FRP1, MEC1, SCKL, SCKL1Protein level used designations for ATR
- FRAP-related protein 1
- FRAP-related protein-1
- MEC1, mitosis entry checkpoint 1, homolog
- Rad3 related protein
- ataxia telangiectasia and Rad3-related protein
- protein kinase ATR
- serine/threonine-protein kinase ATR
您还需要查找其他产品吗？
- ATPOT1B
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- ATPase, Aminophospholipid Transporter, Class I, Type 8B, Member 2
- ATPase Inhibitory Factor 1
- ATPase Family, AAA Domain Containing 5
- ATPase expression protein 1, mitochondrial
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