ATP6V1A 抗体
(ATPase, H+ Transporting, Lysosomal 70kDa, V1 Subunit A (ATP6V1A))
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain A subunit isoforms and is found in all tissues. Transcript variants derived from alternative polyadenylation exist. [provided by RefSeq, Jul 2008].
recommended
ATP6V1A 适用: 人 WB, ELISA, IHC (p), IF 宿主: 小鼠 Monoclonal 4F5 unconjugated
recommended
recommended
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Quantity
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Datasheet
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Quantity
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Datasheet
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Reactivity
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Datasheet
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Latest Publications for our ATP6V1A 抗体
: "Clathrin coat controls synaptic vesicle acidification by blocking vacuolar ATPase activity." in: eLife, Vol. 7, (2018) (PubMed).: "The V-ATPase accessory protein Atp6ap1b mediates dorsal forerunner cell proliferation and left-right asymmetry in zebrafish." in: Developmental biology, Vol. 407, Issue 1, pp. 115-30, (2016) (PubMed).
: "Regulated assembly of vacuolar ATPase is increased during cluster disruption-induced maturation of dendritic cells through a phosphatidylinositol 3-kinase/mTOR-dependent pathway." in: The Journal of biological chemistry, Vol. 289, Issue 3, pp. 1355-63, (2014) (PubMed).
: "Deregulation of subcellular biometal homeostasis through loss of the metal transporter, Zip7, in a childhood neurodegenerative disorder." in: Acta neuropathologica communications, Vol. 2, pp. 25, (2014) (PubMed).
: "V-ATPase proton pumping activity is required for adult zebrafish appendage regeneration." in: PLoS ONE, Vol. 9, Issue 3, pp. e92594, (2014) (PubMed).
: "Hypoxia inducible NOD2 interacts with 3-O-sulfogalactoceramide and regulates vesicular homeostasis." in: Biochimica et biophysica acta, Vol. 1830, Issue 11, pp. 5277-86, (2013) (PubMed).
: "A cytotoxic type III secretion effector of Vibrio parahaemolyticus targets vacuolar H+-ATPase subunit c and ruptures host cell lysosomes." in: PLoS pathogens, Vol. 8, Issue 7, pp. e1002803, (2012) (PubMed).
: "Identifying true protein complex constituents in interaction proteomics: the example of the DMXL2 protein complex." in: Proteomics, Vol. 12, Issue 15-16, pp. 2428-32, (2012) (PubMed).
: "Inhibition of activated Stat3 reverses drug resistance to chemotherapeutic agents in gastric cancer cells." in: Cancer letters, Vol. 315, Issue 2, pp. 198-205, (2011) (PubMed).
: "ErbB2-associated changes in the lysosomal proteome." in: Proteomics, Vol. 11, Issue 14, pp. 2830-8, (2011) (PubMed).
Aliases for ATP6V1A 抗体
ATPase H+ transporting V1 subunit A (ATP6V1A) 抗体ATPase, H+ transporting, lysosomal V1 subunit A (Atp6v1a) 抗体
ATPase, H+ transporting, lysosomal, V1 subunit Aa (atp6v1aa) 抗体
ATPase H+ transporting V1 subunit A (Atp6v1a) 抗体
v-type proton ATPase catalytic subunit A (ANI_1_1468024) 抗体
v-type proton ATPase catalytic subunit A (AOR_1_602134) 抗体
vacuolar ATP synthase subunit A (VHA-A) 抗体
ATPase H+ transporting V1 subunit A L homeolog (atp6v1a.L) 抗体
vacuolar proton pump 3 (vpp3) 抗体
Vacuolar H[+] ATPase 68kD subunit 1 (Vha68-1) 抗体
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