ATP2A2 产品
(ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2))
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This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2008].
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Featured ATP2A2 Categories
ATP2A2 抗体
High quality antibodies with extensive validation data.
ATP2A2 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
ATP2A2 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended ATP2A2 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (8)
Cat. No.
ABIN3021430
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (5)
Cat. No.
ABIN7436261
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC (p)
Validations
- (5)
Cat. No.
ABIN3030067
Quantity
100 μg
Datasheet
Datasheet
Recommended ATP2A2 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6953993
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6953995
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6953994
Quantity
96 tests
Datasheet
Datasheet
Recommended ATP2A2 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1346037
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7398911
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7424083
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our ATP2A2 Products
: "Iron-deficiency anemia reduces cardiac contraction by downregulating RyR2 channels and suppressing SERCA pump activity." in: JCI insight, Vol. 4, Issue 7, (2019) (PubMed).: "SERCA2a: A potential non-invasive biomarker of cardiac allograft rejection." in: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, Vol. 36, Issue 12, pp. 1322-1328, (2018) (PubMed).
: "The E3 ubiquitin ligase NEDD4 is an LC3-interactive protein and regulates autophagy." in: Autophagy, Vol. 13, Issue 3, pp. 522-537, (2017) (PubMed).
: "Regulation of Sarcoplasmic Reticulum Ca2+ ATPase 2 (SERCA2) Activity by Phosphodiesterase 3A (PDE3A) in Human Myocardium: PHOSPHORYLATION-DEPENDENT INTERACTION OF PDE3A1 WITH SERCA2." in: The Journal of biological chemistry, Vol. 290, Issue 11, pp. 6763-76, (2015) (PubMed).
: "Depressed calcium cycling contributes to lower ischemia tolerance in hearts of estrogen-deficient rats." in: Menopause (New York, N.Y.), Vol. 22, Issue 7, pp. 773-82, (2015) (PubMed).
: "Amyloid beta a4 precursor protein-binding family B member 1 (FE65) interactomics revealed synaptic vesicle glycoprotein 2A (SV2A) and sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) as ..." in: Molecular & cellular proteomics : MCP, Vol. 13, Issue 2, pp. 475-88, (2014) (PubMed).
: "SERCA2a gene therapy can improve symptomatic heart failure in δ-sarcoglycan-deficient animals." in: Human gene therapy, Vol. 25, Issue 8, pp. 694-704, (2014) (PubMed).
: "Right ventricular pacing with mechanical dyssynchrony causes apoptosis interruptus and calcium mishandling." in: The Canadian journal of cardiology, Vol. 29, Issue 4, pp. 510-8, (2013) (PubMed).
: "Extramitochondrial domain rich in carbonic anhydrase activity improves myocardial energetics." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, Issue 10, pp. E958-67, (2013) (PubMed).
: "Low density lipoproteins promote unstable calcium handling accompanied by reduced SERCA2 and connexin-40 expression in cardiomyocytes." in: PLoS ONE, Vol. 8, Issue 3, pp. e58128, (2013) (PubMed).
Synonyms and alternative names related to ATP2A2
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 S homeolog (atp2a1.S), ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 (ATP2A2), ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 (Atp2a2), ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 (Atp2a2), ATPase, Ca++ transporting, cardiac muscle, slow twitch 2a (atp2a2a), 9530097L16Rik, ATP2, ATP2A2, atp2a2, atp2b, ATP2B, ca-p60a, D5Wsu150e, dar, DAR, DD, mKIAA4195, serca2, SERCA2, Serca2, SERCA2A, SERCA2B, SercaII, zgc:55380Protein level used designations for ATP2A2
- Calcium ATPase at 60A
- ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
- Atp2a2
- sarcoplasmic/endoplasmic reticulum calcium ATPase 2
- sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like
- ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2
- SR Ca(2+)-ATPase 2
- calcium pump 2
- calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform
- cardiac Ca2+ ATPase
- endoplasmic reticulum class 1/2 Ca(2+) ATPase
- SERCA2
- calcium ATPase
- sarcoplasmic reticulum Ca2+-transport ATPase isoform
- Ca(2+)-transport ATPase class 3
- sarcoplasmic/endoplasmic-reticulum Ca(2+) pump gene 2
- ATPase, Ca++ transporting, slow twitch 2
- sarco(endo)plasmic reticulum Ca(2+)-dependent ATPase 2
- sarco/endoplasmic reticulum Ca2+-ATPase 2
- sarcoplasmic reticulum slow-twitch Ca2 ATPase
- serca2
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