ATM 产品
(Ataxia Telangiectasia Mutated (ATM))
Categories
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates\; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010].
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Featured ATM Categories
ATM 抗体
High quality antibodies with extensive validation data.
ATM ELISA试剂盒
Reliable ELISA kits for a wide range of species.
ATM 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended ATM 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, ELISA, IP, IF, FACS, FM
Validations
- (126)
- (12)
Cat. No.
ABIN6656104
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC, ELISA, IP, IF, FACS, ICC
Validations
- (7)
Cat. No.
ABIN363380
Quantity
0.05 mL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IHC (p), IF (p), IF (cc), FACS, IHC (fro)
Validations
- (1)
- (3)
Cat. No.
ABIN685582
Quantity
100 μL
Datasheet
Datasheet
Recommended ATM ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6953956
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6953957
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Pig
Analytical Method
Quantitative Competition ELISA
Validations
Cat. No.
ABIN778066
Quantity
96 tests
Datasheet
Datasheet
Recommended ATM 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1345994
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1345996
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7393904
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our ATM Products
: "ATM Inhibitor Suppresses Gemcitabine-Resistant BTC Growth in a Polymerase θ Deficiency-Dependent Manner." in: Biomolecules, Vol. 10, Issue 11, (2024) (PubMed).: "DNA-PK participates in pre-rRNA biogenesis independent of DNA double-strand break repair." in: Nucleic acids research, Vol. 52, Issue 11, pp. 6360-6375, (2024) (PubMed).
: "Pre-rRNA Facilitates TopBP1-Mediated DNA Double-Strand Break Response." in: Advanced science (Weinheim, Baden-Wurttemberg, Germany), Vol. 10, Issue 28, pp. e2206931, (2023) (PubMed).
: "Oxidative stress induces chromosomal instability through replication stress in fibroblasts from aged mice." in: Journal of cell science, Vol. 136, Issue 11, (2023) (PubMed).
: "Loss of ribonuclease DIS3 hampers genome integrity in myeloma by disrupting DNA:RNA hybrid metabolism." in: The EMBO journal, Vol. 41, Issue 22, pp. e108040, (2022) (PubMed).
: "Cell cycle-dependent radiosensitivity in mouse zygotes." in: DNA repair, Vol. 117, pp. 103370, (2022) (PubMed).
: "MRN-dependent and independent pathways for recruitment of TOPBP1 to DNA double-strand breaks." in: PloS one, Vol. 17, Issue 8, pp. e0271905, (2022) (PubMed).
: "Hypophosphorylated pRb knock-in mice exhibit hallmarks of aging and vitamin C-preventable diabetes." in: The EMBO journal, Vol. 41, Issue 4, pp. e106825, (2022) (PubMed).
: "IFI16 inhibits DNA repair that potentiates type-I interferon-induced antitumor effects in triple negative breast cancer." in: Cell reports, Vol. 37, Issue 12, pp. 110138, (2022) (PubMed).
: "Evading immune surveillance via tyrosine phosphorylation of nuclear PCNA." in: Cell reports, Vol. 36, Issue 8, pp. 109537, (2022) (PubMed).
Synonyms and alternative names related to ATM
telomere fusion (tefu), ATM serine/threonine kinase L homeolog (atm.L), ATM serine/threonine kinase (atm), ATM serine/threonine kinase (ATM), ataxia telangiectasia mutated (atm), ataxia telangiectasia mutated (EDI_100660), ataxia telangiectasia mutated (CpipJ_CPIJ001772), ataxia telangiectasia mutated (BDBG_08252), ataxia telangiectasia mutated (PAAG_02532), ataxia telangiectasia mutated (MCYG_05088), ataxia telangiectasia mutated (VDBG_06833), ataxia telangiectasia mutated (atm) (ACLA_015700), serine/threonine-protein kinase ATM (LOC5565620), ataxia telangiectasia mutated (MGYG_07634), ataxia telangiectasia mutated (PGTG_14279), ATM serine/threonine kinase (Atm), ataxia telangiectasia mutated (Atm), AI256621, at1, AT1, ATA, ATC, ATD, atdc, ATDC, ATE, ATM, Atm, atm, atm/tefu, C030026E19Rik, CG6535, dATM, Dmel\\CG6535, tef, Tefu, tel1, TEL1, telo1, TELO1, XatmProtein level used designations for ATM
- CG6535-PB
- ataxia telangiectasia mutated
- ataxia telengiesctasia mutated
- ataxia-telangiectasia mutated
- drosophila ATM
- tefu-PB
- chunp9624
- ataxia telangiectasia mutated (includes complementation groups A, C and D)
- ataxia telangiectasia mutated protein
- serine-protein kinase ATM-like
- ataxia telangiectasia mutated (atm)
- A-T mutated
- AT mutated
- TEL1, telomere maintenance 1, homolog
- serine-protein kinase ATM
- Ataxia telangiectasia gene mutated in human beings
- ataxia telangiectasia mutated homolog
- A-T mutated homolog
- ATM (ataxia telangiectasia mutated)
- ataxia telangiectasia gene mutated in human beings
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- ATP Synthase Subunit beta
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- ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit E
- ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1A
- ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B
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- ATP-Binding Protein p29
- ATP-Dependent Clp Protease Proteolytic Subunit 3
- ATP10
- ATP10A
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- ATP10D
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