Ataxin 3 抗体
(Ataxin 3 (ATXN3))
Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by this gene contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is one cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Sep 2009].
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Latest Publications for our Ataxin 3 抗体
: "The Truncated C-terminal Fragment of Mutant ATXN3 Disrupts Mitochondria Dynamics in Spinocerebellar Ataxia Type 3 Models." in: Frontiers in molecular neuroscience, Vol. 10, pp. 196, (2017) (PubMed).: "Ataxin-3 expression correlates with the clinicopathologic features of gastric cancer." in: International journal of clinical and experimental medicine, Vol. 7, Issue 4, pp. 973-81, (2014) (PubMed).
: "Molecular architecture of CAG repeats in human disease related transcripts." in: Journal of molecular biology, Vol. 340, Issue 4, pp. 665-79, (2004) (PubMed).
: "Sequence-dependent and independent inhibition specific for mutant ataxin-3 by small interfering RNA." in: Annals of neurology, Vol. 56, Issue 1, pp. 124-9, (2004) (PubMed).
: "Structural and functional analysis of ataxin-2 and ataxin-3." in: European journal of biochemistry / FEBS, Vol. 271, Issue 15, pp. 3155-70, (2004) (PubMed).
: "The C-type lectin domains of lecticans, a family of aggregating chondroitin sulfate proteoglycans, bind tenascin-R by protein-protein interactions independent of carbohydrate moiety." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 19, pp. 10116-21, (1997) (PubMed).
: "Machado-Joseph disease gene product is a cytoplasmic protein widely expressed in brain." in: Annals of neurology, Vol. 41, Issue 4, pp. 453-62, (1997) (PubMed).
Aliases for Ataxin 3 抗体
ataxin 3 (atxn3) 抗体ataxin 3 (ATXN3) 抗体
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