Ataxin 2 产品
(Ataxin 2 (ATXN2))
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The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. Defects in this gene are the cause of spinocerebellar ataxia type 2 (SCA2). SCA2 belongs to the autosomal dominant cerebellar ataxias type I (ADCA I) which are characterized by cerebellar ataxia in combination with additional clinical features like optic atrophy, ophthalmoplegia, bulbar and extrapyramidal signs, peripheral neuropathy and dementia. SCA2 is caused by expansion of a CAG repeat in the coding region of this gene. This locus has been mapped to chromosome 12, and it has been determined that the diseased allele contains 37-50 CAG repeats, compared to 17-29 in the normal allele. Longer expansions result in earlier onset of the disease. Alternatively spliced transcript variants encoding different isoforms have been identified but their full length sequence has not been determined. [provided by RefSeq, Jan 2010].
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Ataxin 2 抗体
High quality antibodies with extensive validation data.
Ataxin 2 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
Ataxin 2 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
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- (5)
Cat. No.
ABIN7259314
Quantity
200 μL
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Datasheet
Reactivity
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Application
WB, IF, ICC, FACS
Validations
- (7)
Cat. No.
ABIN3028477
Quantity
100 μg
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Datasheet
Reactivity
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Application
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Cat. No.
ABIN872411
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Datasheet
Recommended Ataxin 2 ELISA试剂盒
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Cat. No.
ABIN6962049
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96 tests
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Analytical Method
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- (1)
Cat. No.
ABIN1113614
Quantity
96 tests
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Cat. No.
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Quantity
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Datasheet
Datasheet
Recommended Ataxin 2 蛋白
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Escherichia coli (E. coli)
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Cat. No.
ABIN7121916
Quantity
50 μg
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Reactivity
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Source
Wheat germ
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Cat. No.
ABIN1346193
Quantity
10 μg
Datasheet
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Reactivity
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Source
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Latest Publications for our Ataxin 2 Products
: "Intersection of calorie restriction and magnesium in the suppression of genome-destabilizing RNA-DNA hybrids." in: Nucleic acids research, Vol. 44, Issue 18, pp. 8870-8884, (2016) (PubMed).: "Generation of human-induced pluripotent stem cells to model spinocerebellar ataxia type 2 in vitro." in: Journal of molecular neuroscience : MN, Vol. 51, Issue 2, pp. 237-48, (2013) (PubMed).
: "Ataxin-2-like is a regulator of stress granules and processing bodies." in: PLoS ONE, Vol. 7, Issue 11, pp. e50134, (2012) (PubMed).
: "Multiple common variants for celiac disease influencing immune gene expression. ..." in: Nature genetics, Vol. 42, Issue 4, pp. 295-302, (2010) (PubMed).
: "Expression of ataxin-2 in brains from normal individuals and patients with Alzheimer's disease and spinocerebellar ataxia 2." in: Annals of neurology, Vol. 45, Issue 2, pp. 232-41, (1999) (PubMed).
: "The mouse SCA2 gene: cDNA sequence, alternative splicing and protein expression." in: Human molecular genetics, Vol. 7, Issue 8, pp. 1301-9, (1998) (PubMed).
: "Moderate expansion of a normally biallelic trinucleotide repeat in spinocerebellar ataxia type 2." in: Nature genetics, Vol. 14, Issue 3, pp. 269-76, (1996) (PubMed).
Synonyms and alternative names related to Ataxin 2
ataxin 2 (ATXN2), ataxin 2 (Atxn2), ataxin 2 L homeolog (atxn2.L), 9630045M23Rik, ASL13, ATX2, ATXN2, AW544490, MGC115230, SCA2, Sca2, TNRC13Protein level used designations for Ataxin 2
- ataxin-2
- spinocerebellar ataxia type 2 protein
- trinucleotide repeat containing 13
- trinucleotide repeat-containing gene 13 protein
- spinocerebellar ataxia 2 (olivopontocerebellar ataxia 2, autosomal dominant, ataxin 2)
- spinocerebellar ataxia 2 homolog
- spinocerebellar ataxia type 2 protein homolog
- ataxin 2
- ataxin-2-like
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