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ASXL1 产品

(Additional Sex Combs Like 1 (ASXL1))
This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009].

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Featured ASXL1 Categories

ASXL1 抗体

High quality antibodies with extensive validation data.

ASXL1 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended ASXL1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (1)
  • (5)
Cat. No. ABIN949894
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Application WB, FACS, IF, IHC (p)
Validations
  • (4)
Cat. No. ABIN655084
Quantity 400 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, FACS, IF, IHC (p), EIA
Validations
  • (4)
Cat. No. ABIN950543
Quantity 0.4 mL
Datasheet Datasheet

Recommended ASXL1 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7121702
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1345902
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7319711
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our ASXL1 Products

Balasubramani, Larjo, Bassein, Chang, Hastie, Togher, Lähdesmäki, Rao: "Cancer-associated ASXL1 mutations may act as gain-of-function mutations of the ASXL1-BAP1 complex." in: Nature communications, Vol. 6, pp. 7307, (2015) (PubMed).

Davies, Yip, Fernandez-Mercado, Woll, Agirre, Prosper, Jacobsen, Wainscoat, Pellagatti, Boultwood: "Silencing of ASXL1 impairs the granulomonocytic lineage potential of human CD34? progenitor cells." in: British journal of haematology, Vol. 160, Issue 6, pp. 842-50, (2013) (PubMed).

Fisher, Berger, Randazzo, Brock: "A human homolog of Additional sex combs, ADDITIONAL SEX COMBS-LIKE 1, maps to chromosome 20q11." in: Gene, Vol. 306, pp. 115-26, (2003) (PubMed).

Synonyms and alternative names related to ASXL1

additional sex combs like 1, transcriptional regulator L homeolog (asxl1.L), additional sex combs like 1, transcriptional regulator (ASXL1), additional sex combs like 1, transcriptional regulator (asxl1), additional sex combs like 1 (Asxl1), asxl1, BOPS, MDS, MGC83850, mKIAA0978

Protein level used designations for ASXL1

  • additional sex combs like 1
  • additional sex combs-like protein 1
  • putative Polycomb group protein ASXL1
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