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ASH2L 产品

(Set1/Ash2 Histone Methyltransferase Complex Subunit ASH2 (ASH2L))

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Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis (By similarity).

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Featured ASH2L Categories

ASH2L 抗体

High quality antibodies with extensive validation data.

ASH2L 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

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Cat. No. ABIN7169424
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Cat. No. ABIN5611296
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Recommended ASH2L 蛋白

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Latest Publications for our ASH2L Products

Bieluszewska, Weglewska, Bieluszewski, Lesniewicz, Poreba: "PKA-binding domain of AKAP8 is essential for direct interaction with DPY30 protein." in: The FEBS journal, Vol. 285, Issue 5, pp. 947-964, (2019) (PubMed).

Dharmarajan, Lee, Patel, Skalnik, Cosgrove: "Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases." in: The Journal of biological chemistry, Vol. 287, Issue 33, pp. 27275-89, (2012) (PubMed).

Choi, Boss: "Multiple histone methyl and acetyltransferase complex components bind the HLA-DRA gene." in: PLoS ONE, Vol. 7, Issue 5, pp. e37554, (2012) (PubMed).

Fossati, Dolfini, Donati, Mantovani: "NF-Y recruits Ash2L to impart H3K4 trimethylation on CCAAT promoters." in: PLoS ONE, Vol. 6, Issue 3, pp. e17220, (2011) (PubMed).

Schwab, Patel, Dressler: "Role of PTIP in class switch recombination and long-range chromatin interactions at the immunoglobulin heavy chain locus." in: Molecular and cellular biology, Vol. 31, Issue 7, pp. 1503-11, (2011) (PubMed).

Cao, Chen, Cierpicki, Liu, Basrur, Lei, Dou: "An Ash2L/RbBP5 heterodimer stimulates the MLL1 methyltransferase activity through coordinated substrate interactions with the MLL1 SET domain." in: PLoS ONE, Vol. 5, Issue 11, pp. e14102, (2010) (PubMed).

Pullirsch, Härtel, Kishimoto, Leeb, Steiner, Wutz: "The Trithorax group protein Ash2l and Saf-A are recruited to the inactive X chromosome at the onset of stable X inactivation." in: Development (Cambridge, England), Vol. 137, Issue 6, pp. 935-43, (2010) (PubMed).

Stoller, Huang, Tan, Huang, Zhou, Yang, Gelb, Epstein: "Ash2l interacts with Tbx1 and is required during early embryogenesis." in: Experimental biology and medicine (Maywood, N.J.), Vol. 235, Issue 5, pp. 569-76, (2010) (PubMed).

Amat, Gudas: "RARγ is required for correct deposition and removal of Suz12 and H2A.Z in embryonic stem cells." in: Journal of cellular physiology, Vol. 226, Issue 2, pp. 293-8, (2010) (PubMed).

Tate, Lee, Skalnik: "CXXC finger protein 1 contains redundant functional domains that support embryonic stem cell cytosine methylation, histone methylation, and differentiation." in: Molecular and cellular biology, Vol. 29, Issue 14, pp. 3817-31, (2009) (PubMed).

Synonyms and alternative names related to ASH2L

ASH2 like histone lysine methyltransferase complex subunit (ASH2L), ash2 (absent, small, or homeotic)-like (Drosophila) (Ash2l), ash2 (absent, small, or homeotic)-like (Drosophila) (ash2l), ash2 (absent, small, or homeotic)-like L homeolog (ash2l.L), ASH2 like histone lysine methyltransferase complex subunit (Ash2l), ASH2, ash2-like, ASH2L, ASH2L1, ASH2L2, Bre2, fb34c06, fe38b04, fi20h02, wu:fb34c06, wu:fe38b04, wu:fi20h02, zgc:171444

Protein level used designations for ASH2L

  • ASH2-like protein
  • set1/Ash2 histone methyltransferase complex subunit ASH2
  • ash2-like
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