ASAP2 产品
(ArfGAP with SH3 Domain, Ankyrin Repeat and PH Domain 2 (ASAP2))
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This gene encodes a multidomain protein containing an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology (PH) domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal Src homology 3 (SH3) domain. The protein localizes in the Golgi apparatus and at the plasma membrane, where it colocalizes with protein tyrosine kinase 2-beta (PYK2). The encoded protein forms a stable complex with PYK2 in vivo. This interaction appears to be mediated by binding of its SH3 domain to the C-terminal proline-rich domain of PYK2. The encoded protein is tyrosine phosphorylated by activated PYK2. It has catalytic activity for class I and II ArfGAPs in vitro, and can bind the class III Arf ARF6 without immediate GAP activity. The encoded protein is believed to function as an ARF GAP that controls ARF-mediated vesicle budding when recruited to Golgi membranes. In addition, it functions as a substrate and downstream target for PYK2 and SRC, a pathway that may be involved in the regulation of vesicular transport. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008].
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Featured ASAP2 Categories
Recommended ASAP2 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (2)
Cat. No.
ABIN563842
Quantity
50 μL
Datasheet
Datasheet
Reactivity
Human, Monkey, Mouse, Opossum, Rat
Application
WB
Validations
- (1)
Cat. No.
ABIN960087
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (1)
Cat. No.
ABIN7265659
Quantity
100 μL
Datasheet
Datasheet
Recommended ASAP2 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1345787
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1345789
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3089284
Quantity
1 mg
Datasheet
Datasheet
Synonyms and alternative names related to ASAP2
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 (ASAP2), ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 L homeolog (asap2.L), ArfGAP with SH3 domain, ankyrin repeat and PH domain 1b (asap1b), ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 (asap2), ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 (Asap2), 6530401G17Rik, AMAP2, asap2, CENTB3, DDEF2, ddef2, Ddef2, Gm592, Gm1523, PAG3, PAP, Pap-alpha, SHAG1, si:dkey-37o8.2Protein level used designations for ASAP2
- development and differentiation enhancing factor 2
- development- and differentiation-enhancing factor 2
- ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
- asap1
- PYK2 C terminus-associated protein
- arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2
- centaurin, beta 3
- development and differentiation-enhancing factor 2
- paxillin-associated protein with ARF GAP activity 3
- pyk2 C-terminus-associated protein
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