SARS

Before the emergence of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) in 2003, only 12 other animal or human coronaviruses were known. The discovery of this virus was soon followed by the discovery of the civet and bat SARS-CoV and the human coronaviruses NL63 and HKU1.

The explosive nature of the first SARS epidemic, the high mortality, its transient reemergence a year later, and economic disruptions led to a rush on research of the epidemiological, clinical, pathological, immunological, virological, and other basic scientific aspects of the virus and the disease.(6)

SARS Coronavirus Antibodies & Proteins used in current Research

Products for Coronavirus Proteins

CoV consists of four proteins with the Spike Protein (S-Protein) being the most important surface protein. Find relevant products, antibodies, kits, proteins, assays:

• Spike Protein: anti-CoV Spike Protein antibodies and CoV Spike Proteins
• Envelope Protein: anti-CoV Envelope Protein antibodies
• Membrane Protein: anti-CoV Membrane Protein antibodies
• Nucleocapsid Protein: anti-CoV Nucleocapsid antibodies

SARS-CoV Spike Protein Antibodies

The coronavirus spike contains three segments: a large ectodomain, a single-pass transmembrane anchor, and a short intracellular tail. The ectodomain consists of a receptor-binding subunit S1 and a membrane-fusion subunit S2. During virus entry, S1 binds to a receptor on the host cell surface for viral attachment, and S2 fuses the host and viral membranes, allowing viral genomes to enter host cells.(1)

Below you will find a selection of our CoV spike protein antibodies. Click on the links to see more details.

SARS-CoV Nucleocapsid Protein Antibodies

Of all the coronaviral structural proteins, the N protein is the most abundant throughout infection, both in mRNA and protein levels. Compared to the mRNA levels of other structural genes, the mRNA of the N protein is expressed three to ten times higher at 12-hour post-infection.(2)

Below you will find a selection of our CoV SARS-CoV Nucleocapsid protein antibodies. Take a look at SARS-CoV N antibody ABIN129544. The Immunogen has 90% homology with SARS-CoV-2 Nucleocapsid.

SARS-CoV Envelope Protein Antibodies

The E protein is the smallest of the major structural proteins, but also the most enigmatic. During the replication cycle, E is abundantly expressed inside the infected cell, but only a small portion is incorporated into the virion envelope. The majority of the protein is localised at the site of intracellular trafficking.(4)

Below you will find a selection of our SARS-CoV Envelope protein antibodies. Click on the links to see more details.

SARS-CoV Membrane Protein Antibodies

The coronavirus membrane (M) protein is the key player in virion assembly. One of its functions is to mediate the incorporation of the spikes into the viral envelope. When expressed alone, it accumulates in the Golgi complex in homomultimeric complexes. However, in combination with the E protein, virus-like particles (VLPs) similar to authentic virions in size and shape are assembled, demonstrating that the M and E proteins are the minimal requirements for envelope formation.(4)

Below you will find a selection of our SARS-CoV membrane protein antibodies. Click on the links to see more details.

Products for nCoV Receptors

Current research indicates that ACE2 is the key receptor that enables nCoV to enter the cells.⁽⁵⁾ Antibodies and kits related to ACE2 and other receptors discussed in the literature are listed below.

References