Respiratory Syncytial Virus (RSV)

Respiratory Syncytial Virus (RSV) (Synonym: Human Orthopneumovirus, HRSV) is the only known human pathogen of the genus Pneumovirus, family Paramyxoviridae, first isolated in 1956 from a chimpanzee with coryza. RSV is a negative sense, enveloped RNA virus RSV is a common cause of respiratory tract infections, especially in young children.

The virion varies in shape and size with a diameter between 120 and 300 nm. It has a non-segmented genome so, unlike influenza, it does not have the capacity for re-assortment of genome segments and thus to undergo antigenic shifts that have the potential to cause large pandemics. The15.2-kilobase genome encodes 11 viral proteins.

RSV has two separate genes coding for nonstructural proteins (NSP1, NSP2) that suppress the host's innate immunity, a unique feature in the Paramyxoviridae family. Suppression is mediated primarily by type I interferon (IFN). The virions display three surface proteins: G (attachment), F (fusion) and SH protein. Glycoproteins F and G carry neutralizing epitopes and bind to disaccharide subunits called GAGs and RhoA respectively. A secreted form of the G protein contains a CX3C chemokine motif that may be important in modulating immune responses to infection. The large (L) protein is a viral RNA-dependent RNA polymerase that contains multiple enzyme functions required for RSV replication, it enters the genome and mRNA is transcribed. The M (matrix) protein co-ordinates the assembly of the envelope proteins with N (nucleocapsid) and P (phospho) proteins.

The RSV antibodies (eg ABIN5668206 or ABIN238061) , ELISA Kits and proteins can also be useful for conducting Cross Reactivity Analysis for other virus-related diagnostic tests (i.e. COVID-19 serological tests). Related Products: SARS-CoV-2 Antibodies, SARS-CoV-2 Proteins, SARS-CoV-2 ELISA Kits