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SARS-CoV-2 Non-Structural Proteins
SARS-CoV-2 proteins can be grouped in two major classes, structural and nonstrcutural proteins (NSPs). While structural proteins, either hold the RNA genome or are built into the viral envelope, a nonstructural protein encoded by a virus is expressed in infected cells, but not incorporated into the virion particle. NSPs include the various enzymes and transcription factors the virus uses to replicate itself, such as a viral protease, an RNA replicase and some means to control the host.
After host cell infection SARS-CoV-2 polyproteins pp1a and pp1ab, are translated which are cleaved by the Papain-like protease (Plpro) and 3C-like protease (3CLpro). Cleaved proteins are funcional NSPs like helicase or the RNA-dependent RNA polymerase (RdRp) that catalyzes the replication of RNA from an RNA template and is responsible for the replication of SARS-CoV-2 structural protein RNA. The RNA helicase helps to unwind dsRNA.
NSP1
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NSP2
NSP3
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NSP4
NSP5
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NSP6
NSP7
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NSP8
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NSP9
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NSP10
NSP12
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NSP13
NSP14
NSP15
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NSP16
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Heterodimer Proteins
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ORFs
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