Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by inflammation and progressive destruction of synovial joints. Affecting approximately 1% of the global population, RA leads to significant morbidity and disability. The pathogenesis of RA involves a complex interplay of genetic, environmental, and immunological factors. Despite advances in treatment, there remains an unmet need for more targeted and effective therapeutics. antibodies-online offers antibodies and proteins for key RA targets which support development of novelle therapeutics.
What is Rheumatoid Arthritis?
Rheumatoid arthritis is an autoimmune disease wherein the immune system mistakenly attacks the synovial membrane, leading to inflammation, joint destruction, and systemic manifestations. The disease is characterized by persistent synovitis, autoantibody production (notably rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPA)), and cartilage and bone erosion. The etiology of RA is multifactorial, involving genetic susceptibility, environmental triggers (such as smoking), and hormonal influences.
Autoantibodies
Autoantibodies in RA, such as rheumatoid factor and anti-citrullinated protein antibodies, contribute to inflammation and joint damage by forming immune complexes that drive the disease pathology. FcRn (neonatal Fc receptor) protects these IgG autoantibodies from degradation by recycling them back into the bloodstream, thus sustaining their pathogenic activity. FcRn-targeting antibodies can help reduce RA disease activity by promoting the degradation of these harmful autoantibodies, thereby lowering their levels and mitigating the autoimmune response.
Discover FcRn AntibodiesWhat Antigens are Involved in Rheumatoid Arthritis Pathogenesis?
The shared epitope alleles of HLA-DRB1 play a key role in presenting citrullinated peptides to T cells, leading to an autoimmune response against joint tissues. This process is influenced by genetic predisposition and environmental factors, contributing to the complex etiology of RA. Citrullination is a post-translational modification where the amino acid arginine in proteins is converted into citrulline. This modification can create new epitopes that are recognized as non-self by the immune system. HLA-DRB1 alleles with the SE motif have a higher affinity for binding these citrullinated peptides, which may contribute to the breakdown of tolerance and the development of autoimmunity in RA.
These immune complexes are deposited in the synovium, triggering inflammation and recruitment of immune cells. T cells, particularly Th1 and Th17 subsets, play a pivotal role in sustaining the inflammatory response by producing pro-inflammatory cytokines such as TNF-α, IL-1, and IL-6. B cells contribute to the pathogenesis by producing autoantibodies and presenting antigens to T cells. The chronic inflammation results in synovial hyperplasia and the formation of pannus, which invades and destroys cartilage and bone.
Human Leukocyte Antigen Targets in Rheumatoid Arthritis
These research targets play a crucial role in advancing our understanding of the mechanisms behind rheumatoid arthritis, providing valuable tools to further investigate the immune responses that drive disease progression and offering potential pathways for therapeutic intervention.
What are Rheumatoid Arthritis Antigen Markers?
Rheumatoid arthritis is associated with several antigenic markers that aid in diagnosis and prognosis. The most significant markers include rheumatoid factor and anti-citrullinated protein antibodies. RF is an autoantibody that targets the Fc region of IgG and is present in approximately 70-80% of RA patients. ACPA targets citrullinated peptides and proteins, such as vimentin, fibrinogen, and enolase, and is highly specific for RA. The presence of these markers is associated with more severe disease and joint damage. Additionally, other biomarkers like C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) are used to assess inflammation and disease activity.
Therapeutic Approaches for RA
Current therapeutics for RA include nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, conventional disease-modifying antirheumatic drugs (DMARDs) such as methotrexate, and biologic agents. Biologics, including TNF inhibitors (e.g., adalimumab, infliximab), IL-6 receptor antagonists (e.g., tocilizumab), and B cell depleting agents (e.g., rituximab), have significantly improved disease outcomes. However, not all patients respond adequately to existing therapies, and some experience adverse effects. There is a critical need for novel antibodies or proteins that target specific pathogenic mechanisms, such as T cell co-stimulation, JAK-STAT signaling pathways, and new autoantigens identified through advanced proteomics. Developing more selective and potent biologics or small molecules will enhance treatment efficacy, reduce side effects, and improve the quality of life for RA patients.
Available Biosimilar Antibodies for RA Targets
In conclusion, ongoing research into the molecular and immunological underpinnings of RA is essential for the development of next-generation therapeutics. By identifying new antigenic targets and understanding their role in disease pathogenesis, we can create more precise and effective treatments for rheumatoid arthritis.
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References
- : "The pathogenesis of rheumatoid arthritis." in: Immunity, Vol. 55, Issue 12, pp. 2255-2270, (2022) (PubMed).
- : "Evolving concepts of rheumatoid arthritis." in: Nature, Vol. 423, Issue 6937, pp. 356-61, (2003) (PubMed).
- : "The immunology of rheumatoid arthritis." in: Nature immunology, Vol. 22, Issue 1, pp. 10-18, (2021) (PubMed).
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