APPL2 抗体
(Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2))
The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12\;22)(q24.1\;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome. [provided by RefSeq, Oct 2011].
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APPL2 抗体 by 适用
Find APPL2 抗体 for a variety of species such as anti-Human APPL2, anti-Rat APPL2, anti-Mouse APPL2. The species listed below are among those available. Click on a link to go to the corresponding products.
APPL2 抗体 by 应用范围
Find APPL2 抗体 validated for a specific application such as WB, ELISA, IF, IHC. Some of the available applications are listed below. Click on a link to go to the corresponding products.
APPL2 抗体 by 抗体来源
Find APPL2 抗体 with a specific 抗体来源. The 抗体来源 listed below are among those available. Click on a link to go to the corresponding products.
APPL2 抗体 by 抗原表位
Find APPL2 抗体 with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.
APPL2 抗体 by 克隆形成能力
Find available monoclonal or polyclonal APPL2 抗体. Click on a link to go to the corresponding products.
APPL2 抗体 by 克隆
Find APPL2 抗体 with a specific 克隆. The 克隆 listed below are among those available. Click on a link to go to the corresponding products.
APPL2 抗体 by 标记
Find APPL2 抗体 with a specific conjugate such as Biotin, FITC, HRP. The conjugates listed below are among those available. Click on a link to go to the corresponding products.
Popular APPL2 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (4)
Cat. No.
ABIN527415
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (1)
- (3)
Cat. No.
ABIN527414
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IF, IHC
Validations
- (2)
Cat. No.
ABIN7149505
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC
Validations
- (1)
Cat. No.
ABIN7265444
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA
Validations
Cat. No.
ABIN7149508
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
ELISA
Validations
Cat. No.
ABIN7149506
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA
Validations
Cat. No.
ABIN7111302
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
Cat. No.
ABIN7467924
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
Cat. No.
ABIN1807972
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
Cat. No.
ABIN2568583
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Rat
Application
WB, IF
Validations
Cat. No.
ABIN2568582
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
Cat. No.
ABIN2568584
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, ICC, IHC (p)
Validations
Cat. No.
ABIN7467925
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
Cat. No.
ABIN1963174
Quantity
200 μL
Datasheet
Datasheet
Latest Publications for our APPL2 抗体
: "Acute physical exercise increases APPL1/PI3K signaling in the hypothalamus of lean mice." in: The European journal of neuroscience, (2019) (PubMed).: "The reversal effect of physical exercise on aging-related increases in APPL2 content in skeletal muscle." in: Life sciences, Vol. 210, pp. 209-213, (2018) (PubMed).
: "Acute physical exercise increases the adaptor protein APPL1 in the hypothalamus of obese mice." in: Cytokine, Vol. 110, pp. 87-93, (2018) (PubMed).
: "The adaptor protein APPL1 increases glycogen accumulation in rat skeletal muscle through activation of the PI3-kinase signalling pathway." in: The Journal of endocrinology, Vol. 210, Issue 1, pp. 81-92, (2011) (PubMed).
Aliases for APPL2 抗体
adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 (Appl2) 抗体adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 (APPL2) 抗体
adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 L homeolog (appl2.L) 抗体
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 (appl2) 抗体
adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 (appl2) 抗体
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 (Appl2) 抗体
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