APPL1 产品
(Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1))
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The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus. [provided by RefSeq, Jul 2008].
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Featured APPL1 Categories
Recommended APPL1 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN7234818
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (3)
Cat. No.
ABIN565220
Quantity
50 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7149501
Quantity
100 μg
Datasheet
Datasheet
Recommended APPL1 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6205982
Quantity
96 tests
Datasheet
Datasheet
Recommended APPL1 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7121695
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1345406
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1345408
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our APPL1 Products
: "APPL1 promotes glucose uptake in response to mechanical stretch via the PKCζ-non-muscle myosin IIa pathway in C2C12 myotubes." in: Cellular signalling, Vol. 28, Issue 11, pp. 1694-702, (2016) (PubMed).: "Fiber type-specific differences in glucose uptake by single fibers from skeletal muscles of 9- and 25-month-old rats." in: The journals of gerontology. Series A, Biological sciences and medical sciences, Vol. 67, Issue 12, pp. 1286-94, (2012) (PubMed).
: "A novel method to measure glucose uptake and myosin heavy chain isoform expression of single fibers from rat skeletal muscle." in: Diabetes, Vol. 61, Issue 5, pp. 995-1003, (2012) (PubMed).
: "Effects of polysaccharides from Morchella conica on nitric oxide production in lipopolysaccharide-treated macrophages." in: Applied microbiology and biotechnology, Vol. 94, Issue 3, pp. 763-71, (2012) (PubMed).
: "Mechanisms for increased insulin-stimulated Akt phosphorylation and glucose uptake in fast- and slow-twitch skeletal muscles of calorie-restricted rats." in: American journal of physiology. Endocrinology and metabolism, Vol. 300, Issue 6, pp. E966-78, (2011) (PubMed).
: "Insulin resistance for glucose uptake and Akt2 phosphorylation in the soleus, but not epitrochlearis, muscles of old vs. adult rats." in: Journal of applied physiology (Bethesda, Md. : 1985), Vol. 108, Issue 6, pp. 1631-40, (2010) (PubMed).
: "APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function." in: Nature cell biology, Vol. 8, Issue 5, pp. 516-23, (2006) (PubMed).
: "Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2." in: Oncogene, Vol. 18, Issue 35, pp. 4891-8, (1999) (PubMed).
Synonyms and alternative names related to APPL1
adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 (APPL1), adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 (Appl1), adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 (Appl1), 2900057D21Rik, 7330406P05Rik, AI585782, APPL, AW209077, BB022931, C88264, DIP13, DIP13alpha, RGD1309388Protein level used designations for APPL1
- AKT2 interactor
- DCC-interacting protein 13-alpha
- adapter protein containing PH domain, PTB domain and leucine zipper motif 1
- adaptor protein containing pH domain, PTB domain and leucine zipper motif 1
- dip13-alpha
- signaling adaptor protein DIP13alpha
- DIP13 alpha
- adaptor protein APPL like
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