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APOBEC3H 产品

(Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3H (APOBEC3H))

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This gene encodes a member of the apolipoprotein B mRNA-editing enzyme catalytic polypeptide 3 family of proteins. The encoded protein is a cytidine deaminase that has antiretroviral activity by generating lethal hypermutations in viral genomes. Polymorphisms and alternative splicing in this gene influence its antiretroviral activity and are associated with increased resistence to human immunodeficiency virus type 1 infection in certain populations. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009].

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Featured APOBEC3H Categories

APOBEC3H 抗体

High quality antibodies with extensive validation data.

APOBEC3H 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended APOBEC3H 抗体

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Reactivity Human
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Cat. No. ABIN6259988
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Reactivity Human, Monkey
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Cat. No. ABIN6749340
Quantity 100 μL
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Recommended APOBEC3H 蛋白

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Quantity 10 μg
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Reactivity Human
Source Tobacco (Nicotiana tabacum)
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Cat. No. ABIN3087960
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Reactivity Rhesus Monkey
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Cat. No. ABIN1620112
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Latest Publications for our APOBEC3H Products

Ebrahimi, Richards, Carpenter, Wang, Ikeda, Becker, Cheng, McCann, Shaban, Salamango, Starrett, Lingappa, Yong, Brown, Harris: "Genetic and mechanistic basis for APOBEC3H alternative splicing, retrovirus restriction, and counteraction by HIV-1 protease." in: Nature communications, Vol. 9, Issue 1, pp. 4137, (2019) (PubMed).

Wang, Becker, Shi, Lauer, Salamango, Aihara, Shaban, Harris: "The Role of RNA in HIV-1 Vif-Mediated Degradation of APOBEC3H." in: Journal of molecular biology, Vol. 431, Issue 24, pp. 5019-5031, (2019) (PubMed).

Salamango, Becker, McCann, Cheng, Demir, Amaro, Brown, Shaban, Harris: "APOBEC3H Subcellular Localization Determinants Define Zipcode for Targeting HIV-1 for Restriction." in: Molecular and cellular biology, Vol. 38, Issue 23, (2018) (PubMed).

Starrett, Luengas, McCann, Ebrahimi, Temiz, Love, Feng, Adolph, Chelico, Law, Carpenter, Harris: "The DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis." in: Nature communications, Vol. 7, pp. 12918, (2016) (PubMed).

Ooms, Letko, Simon: "The Structural Interface between HIV-1 Vif and Human APOBEC3H." in: Journal of virology, Vol. 91, Issue 5, (2016) (PubMed).

Refsland, Hultquist, Luengas, Ikeda, Shaban, Law, Brown, Reilly, Emerman, Harris: "Natural polymorphisms in human APOBEC3H and HIV-1 Vif combine in primary T lymphocytes to affect viral G-to-A mutation levels and infectivity." in: PLoS genetics, Vol. 10, Issue 11, pp. e1004761, (2014) (PubMed).

Shaban, Shi, Lauer, Carpenter, Richards, Salamango, Wang, Lopresti, Banerjee, Levin-Klein, Brown, Aihara, Harris: "The Antiviral and Cancer Genomic DNA Deaminase APOBEC3H Is Regulated by an RNA-Mediated Dimerization Mechanism." in: Molecular cell, Vol. 69, Issue 1, pp. 75-86.e9 (PubMed).

Synonyms and alternative names related to APOBEC3H

apolipoprotein B mRNA editing enzyme catalytic subunit 3H (APOBEC3H), A3H, APOBEC3A, ARP10

Protein level used designations for APOBEC3H

  • APOBEC-related protein 10
  • ARP-10
  • DNA dC->dU-editing enzyme APOBEC-3H
  • apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3H
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