APOBEC3A 产品
(Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3A (APOBEC3A))
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This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012].
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APOBEC3A 抗体
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Latest Publications for our APOBEC3A Products
: "HIV-1 Vpr induces interferon-stimulated genes in human monocyte-derived macrophages." in: PLoS ONE, Vol. 9, Issue 8, pp. e106418, (2014) (PubMed).: "Innate immune signaling induces high levels of TC-specific deaminase activity in primary monocyte-derived cells through expression of APOBEC3A isoforms." in: The Journal of biological chemistry, Vol. 285, Issue 36, pp. 27753-66, (2010) (PubMed).
: "Interaction of Vpx and apolipoprotein B mRNA-editing catalytic polypeptide 3 family member A (APOBEC3A) correlates with efficient lentivirus infection of monocytes." in: The Journal of biological chemistry, Vol. 285, Issue 16, pp. 12248-54, (2010) (PubMed).
: "APOBEC3 proteins mediate the clearance of foreign DNA from human cells." in: Nature structural & molecular biology, Vol. 17, Issue 2, pp. 222-9, (2010) (PubMed).
: "Effects of structural variations of APOBEC3A and APOBEC3B genes in chronic hepatitis B virus infection." in: Hepatology research : the official journal of the Japan Society of Hepatology, Vol. 39, Issue 12, pp. 1159-68, (2009) (PubMed).
: "APOBEC deaminases-mutases with defensive roles for immunity." in: Science in China. Series C, Life sciences / Chinese Academy of Sciences, Vol. 52, Issue 10, pp. 893-902, (2009) (PubMed).
: "Targeting APOBEC3A to the viral nucleoprotein complex confers antiviral activity." in: Retrovirology, Vol. 4, pp. 61, (2007) (PubMed).
: "Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business." in: Trends in genetics : TIG, Vol. 19, Issue 4, pp. 207-16, (2003) (PubMed).
: "An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22." in: Genomics, Vol. 79, Issue 3, pp. 285-96, (2002) (PubMed).
Synonyms and alternative names related to APOBEC3A
apolipoprotein B mRNA editing enzyme catalytic subunit 3A (APOBEC3A), apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A (APOBEC3Z1), apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3Z1 (APOBEC3Z1), similar to ARP10 protein (APOBEC3A), apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A (APOBEC3A), A3A, APOBEC3A, APOBEC3Z1, ARP3, bK150C2.1, PHRBNProtein level used designations for APOBEC3A
- DNA dC->dU-editing enzyme APOBEC-3A
- phorbolin 1
- phorbolin-1
- probable DNA dC->dU-editing enzyme APOBEC-3A
- apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
- similar to ARP10 protein
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