-
- 抗原 See all LRP5 抗体
- LRP5 (Low Density Lipoprotein Receptor-Related Protein 5 (LRP5))
-
适用
- 人
-
宿主
- 小鼠
-
克隆类型
- 单克隆
-
标记
- This LRP5 antibody is un-conjugated
-
应用范围
- ELISA, Flow Cytometry (FACS)
- 原理
- LRP5 Antibody
- 纯化方法
- Purified antibody
- 免疫原
- Purified recombinant fragment of human LRP5 expressed in E. Coli.
- 克隆位点
- 2B11
- 亚型
- IgG1
- Top Product
- Discover our top product LRP5 Primary Antibody
-
-
- 应用备注
-
ELISA: 1/10000
FCM: 1/200 - 1/400
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 缓冲液
- Purified antibody in PBS with 0.05 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
-
-
Low-density lipoprotein receptor-related protein 5 (LRP5) variation in fracture prone children." in: Bone, Vol. 46, Issue 4, pp. 940-5, (2010) (PubMed).
: "A1330V variant of the low-density lipoprotein receptor-related protein 5 (LRP5) gene decreases Wnt signaling and affects the total body bone mineral density in Japanese women." in: Endocrine journal, Vol. 56, Issue 4, pp. 625-31, (2009) (PubMed).
: "
-
Low-density lipoprotein receptor-related protein 5 (LRP5) variation in fracture prone children." in: Bone, Vol. 46, Issue 4, pp. 940-5, (2010) (PubMed).
-
- 抗原
- LRP5 (Low Density Lipoprotein Receptor-Related Protein 5 (LRP5))
- 别名
- LRP5 (LRP5 产品)
- 背景
-
Description: This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy.
Aliases: HBM, LR3, OPS, EVR1, EVR4, LRP7, OPPG, BMND1, OPTA1, VBCH2
- 分子量
- 179kDa
- 基因ID
- 4041
- HGNC
- 4041
- UniProt
- O75197
- 途径
- WNT signaling, Stem Cell Maintenance, Positive Regulation of fat Cell Differentiation
-