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ALPL 抗体

ALPL 适用: 人 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 2F4 unconjugated
产品编号 ABIN969500
发货至: 中国
  • 抗原 See all ALPL 抗体
    ALPL (Alkaline Phosphatase, Liver/bone/kidney (ALPL))
    适用
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    宿主
    • 79
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    小鼠
    克隆类型
    • 82
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    单克隆
    标记
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    This ALPL antibody is un-conjugated
    应用范围
    • 65
    • 37
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    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)
    纯化方法
    purified
    免疫原
    Purified recombinant fragment of human ALPL expressed in E. coli.
    克隆位点
    2F4
    亚型
    IgG1
    Top Product
    Discover our top product ALPL Primary Antibody
  • 应用备注
    ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, FCM: 1:200 - 1:400
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified antibody in PBS with 0.05 % sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C/-20 °C
    储存方法
    4°C, -20°C for long term storage
  • Kannampuzha, Tupy, Pritzker: "Mercaptopyruvate inhibits tissue-nonspecific alkaline phosphatase and calcium pyrophosphate dihydrate crystal dissolution." in: The Journal of rheumatology, Vol. 36, Issue 12, pp. 2758-65, (2009) (PubMed).

    Kanazawa, Yamaguchi, Yamamoto, Yamauchi, Yano, Sugimoto: "Serum osteocalcin/bone-specific alkaline phosphatase ratio is a predictor for the presence of vertebral fractures in men with type 2 diabetes." in: Calcified tissue international, Vol. 85, Issue 3, pp. 228-34, (2009) (PubMed).

  • 抗原
    ALPL (Alkaline Phosphatase, Liver/bone/kidney (ALPL))
    别名
    ALPL (ALPL 产品)
    别名
    ALP antibody, iap antibody, alpl antibody, AP-TNAP antibody, APTNAP antibody, HOPS antibody, TNAP antibody, TNSALP antibody, Akp-2 antibody, Akp2 antibody, PHOA antibody, TNS-AP antibody, alkaline phosphatase, liver/bone/kidney L homeolog antibody, alkaline phosphatase, liver/bone/kidney antibody, alkaline phosphatase, intestinal, gene 2 antibody, alkaline phosphatase, liver/bone/kidney pseudogene antibody, alpl.L antibody, ALPL antibody, alpi.2 antibody, LOC100031702 antibody, Alpl antibody
    背景

    Description: There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization, however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described.

    Aliases: HOPS, TNAP, APTNAP, TNSALP, AP-TNAP

    分子量
    57.3 kDa
    基因ID
    249
    HGNC
    249
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