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MTDH 抗体

MTDH 适用: 人 WB, IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 2F11C3 unconjugated
产品编号 ABIN969496
发货至: 中国
  • 抗原 See all MTDH 抗体
    MTDH (Metadherin (MTDH))
    适用
    • 49
    • 18
    • 7
    • 2
    • 1
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    宿主
    • 41
    • 6
    • 3
    小鼠
    克隆类型
    • 46
    • 4
    单克隆
    标记
    • 28
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    • 1
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    • 1
    • 1
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    This MTDH antibody is un-conjugated
    应用范围
    • 40
    • 14
    • 13
    • 13
    • 10
    • 9
    • 9
    • 8
    • 7
    • 4
    • 3
    • 2
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)
    纯化方法
    purified
    免疫原
    Purified recombinant fragment of human Metadherin expressed in E. coli.
    克隆位点
    2F11C3
    亚型
    IgG1
    Top Product
    Discover our top product MTDH Primary Antibody
  • 应用备注
    ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, FCM: 1:200 - 1:400
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Antibody are purified by protein G affinity chromatography. Liquid in PBS containing 50 % glycerol and 0.03 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C/-20 °C
    储存方法
    4°C, -20°C for long term storage
  • Britt, Yang, Yang, Flanagan, Callanan, Lim, Lin, Hixson: "Identification of a novel protein, LYRIC, localized to tight junctions of polarized epithelial cells." in: Experimental cell research, Vol. 300, Issue 1, pp. 134-48, (2004) (PubMed).

    Brown, Ruoslahti: "Metadherin, a cell surface protein in breast tumors that mediates lung metastasis." in: Cancer cell, Vol. 5, Issue 4, pp. 365-74, (2004) (PubMed).

  • 抗原
    MTDH (Metadherin (MTDH))
    别名
    Metadherin (MTDH 产品)
    别名
    MGC75963 antibody, 2610103J23Rik antibody, 3D3 antibody, 3D3/Lyric antibody, AEG-1 antibody, AV353288 antibody, D8Bwg1112e antibody, Lyric antibody, AEG1 antibody, LYRIC antibody, LYRIC/3D3 antibody, metadherin antibody, mtdh antibody, MTDH antibody, Mtdh antibody
    背景

    Description: Metadherin (Metastasis adhesion protein), also known as MTDH, LYsine-RIch CEACAM1 co-isolated (LYRIC), is a novel protein that localizes with the tight junction proteins ZO-1 and occludin in polarized epithelial cells. At the tight junction, it acts not as a structural component, but is rather recruited during the maturation of the tight junction complex. Metadherin is overexpressed in breast cancer tissue and breast tumor xenografts, while much lower levels are expressed in normal breast tissue. Metadherin binds to lung vasculature, one of the four common sites of breast cancer metastasis, through a C-terminal segment in the extracellular domain, blocking this lung-homing domain with antibodies or inhibiting metadherin with siRNA has been reported to inhibit breast cancer metastasis.

    Aliases: 3D3, AEG1, LYRIC, MTDH

    分子量
    64 kDa
    基因ID
    92140
    HGNC
    92140
    途径
    Cellular Response to Molecule of Bacterial Origin, Cell-Cell Junction Organization
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