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XBP1 抗体

XBP1 适用: 人 ELISA 宿主: 小鼠 Monoclonal 1C4 unconjugated
产品编号 ABIN969462
发货至: 中国
  • 抗原 See all XBP1 抗体
    XBP1 (X-Box Binding Protein 1 (XBP1))
    适用
    • 75
    • 42
    • 10
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    宿主
    • 73
    • 12
    • 1
    小鼠
    克隆类型
    • 74
    • 12
    单克隆
    标记
    • 43
    • 7
    • 6
    • 5
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This XBP1 antibody is un-conjugated
    应用范围
    • 73
    • 44
    • 28
    • 19
    • 14
    • 13
    • 12
    • 9
    • 6
    • 4
    • 3
    • 3
    • 2
    • 1
    ELISA
    原理
    XBP1 Antibody
    纯化方法
    Ascitic fluid
    免疫原
    Purified recombinant fragment of human XBP1 expressed in E. Coli.
    克隆位点
    1C4
    亚型
    IgG1
    Top Product
    Discover our top product XBP1 Primary Antibody
  • 应用备注
    ELISA: 1/10000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Ascitic fluid containing 0.03 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Martino, Olsen, Fulcher, Wolfgang, ONeal, Ribeiro: "Airway epithelial inflammation-induced endoplasmic reticulum Ca2+ store expansion is mediated by X-box binding protein-1." in: The Journal of biological chemistry, Vol. 284, Issue 22, pp. 14904-13, (2009) (PubMed).

    Schardt, Weber, Eyholzer, Mueller, Pabst: "Activation of the unfolded protein response is associated with favorable prognosis in acute myeloid leukemia." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 15, Issue 11, pp. 3834-41, (2009) (PubMed).

    Jiang, Yang, Thorne, Zhu, Hersey, Zhang: "Human melanoma cells under endoplasmic reticulum stress acquire resistance to microtubule-targeting drugs through XBP-1-mediated activation of Akt." in: Neoplasia (New York, N.Y.), Vol. 11, Issue 5, pp. 436-47, (2009) (PubMed).

  • 抗原
    XBP1 (X-Box Binding Protein 1 (XBP1))
    别名
    XBP1 (XBP1 产品)
    别名
    treb5 antibody, xXBP1 antibody, xbp2 antibody, XBP1P1 antibody, XBPP1 antibody, xbp1 antibody, TREB5 antibody, XBP-1 antibody, XBP2 antibody, D11Ertd39e antibody, TREB-5 antibody, HTF antibody, cb918 antibody, id:ibd1195 antibody, trebf antibody, wu:fb02h05 antibody, wu:fb63f10 antibody, xbp1a antibody, xbp1b antibody, X-box binding protein 1 antibody, X-box binding protein 1 L homeolog antibody, xbp1 antibody, XBP1 antibody, Xbp1 antibody, xbp1.L antibody
    背景

    Description: This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5.

    Aliases: XBP2, TREB5, XBP1

    分子量
    28kDa
    基因ID
    7494
    HGNC
    7494
    UniProt
    P17861
    途径
    ER-Nucleus Signaling, Unfolded Protein Response
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