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SLUG 抗体

SNAI2 适用: 人 ELISA 宿主: 小鼠 Monoclonal 2H5 unconjugated
产品编号 ABIN969410
发货至: 中国
  • 抗原 See all SLUG (SNAI2) 抗体
    SLUG (SNAI2) (Snail Family Zinc Finger 2 (SNAI2))
    适用
    • 48
    • 17
    • 13
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    宿主
    • 38
    • 10
    小鼠
    克隆类型
    • 39
    • 8
    单克隆
    标记
    • 30
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    This SLUG antibody is un-conjugated
    应用范围
    • 25
    • 18
    • 12
    • 8
    • 3
    • 3
    • 2
    • 1
    • 1
    ELISA
    原理
    SNAI2 Antibody
    纯化方法
    Ascitic fluid
    免疫原
    Purified recombinant fragment of human SNAI2 expressed in E. Coli.
    克隆位点
    2H5
    亚型
    IgG1
    Top Product
    Discover our top product SNAI2 Primary Antibody
  • 应用备注
    ELISA: 1/10000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Ascitic fluid containing 0.03 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Saegusa, Hashimura, Kuwata, Okayasu: "Requirement of the Akt/beta-catenin pathway for uterine carcinosarcoma genesis, modulating E-cadherin expression through the transactivation of slug." in: The American journal of pathology, Vol. 174, Issue 6, pp. 2107-15, (2009) (PubMed).

    Medici, Hay, Olsen: "Snail and Slug promote epithelial-mesenchymal transition through beta-catenin-T-cell factor-4-dependent expression of transforming growth factor-beta3." in: Molecular biology of the cell, Vol. 19, Issue 11, pp. 4875-87, (2008) (PubMed).

  • 抗原
    SLUG (SNAI2) (Snail Family Zinc Finger 2 (SNAI2))
    别名
    SNAI2 (SNAI2 产品)
    背景

    Description: This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity.The tumor suppressor protein p53 induces Slug expression in -irradiated cells, Slug protects damaged cells from apoptosis by repressing p53-induced transcription of the proapoptotic Bcl-2 family protein Puma. Mutations in this gene may be associated with sporatic cases of neural tube defects.

    Aliases: SLUG, WS2D, SLUGH1, MGC10182, SNAI2

    分子量
    30kDa
    基因ID
    6591
    HGNC
    6591
    UniProt
    O43623
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