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Sonic Hedgehog 抗体

SHH 适用: 人 ELISA 宿主: 小鼠 Monoclonal 8G3 unconjugated
产品编号 ABIN969395
发货至: 中国
  • 抗原 See all Sonic Hedgehog (SHH) 抗体
    Sonic Hedgehog (SHH)
    适用
    • 65
    • 50
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    • 1
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    宿主
    • 73
    • 11
    • 8
    • 1
    • 1
    小鼠
    克隆类型
    • 68
    • 26
    单克隆
    标记
    • 51
    • 8
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    • 2
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    • 1
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    This Sonic Hedgehog antibody is un-conjugated
    应用范围
    • 69
    • 27
    • 23
    • 14
    • 13
    • 11
    • 9
    • 7
    • 6
    • 6
    • 5
    • 4
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    ELISA
    原理
    SHH Antibody
    纯化方法
    Ascitic fluid
    免疫原
    Purified recombinant fragment of human SHH expressed in E. Coli.
    克隆位点
    8G3
    亚型
    IgG1
    Top Product
    Discover our top product SHH Primary Antibody
  • 应用备注
    ELISA: 1/10000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Ascitic fluid containing 0.03 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Dia, Mejia: "Lunasin promotes apoptosis in human colon cancer cells by mitochondrial pathway activation and induction of nuclear clusterin expression." in: Cancer letters, Vol. 295, Issue 1, pp. 44-53, (2010) (PubMed).

    Dierker, Dreier, Migone, Hamer, Grobe: "Heparan sulfate and transglutaminase activity are required for the formation of covalently cross-linked hedgehog oligomers." in: The Journal of biological chemistry, Vol. 284, Issue 47, pp. 32562-71, (2009) (PubMed).

    Bailey, Mohr, Hollingsworth: "Sonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancer." in: Oncogene, Vol. 28, Issue 40, pp. 3513-25, (2009) (PubMed).

  • 抗原
    Sonic Hedgehog (SHH)
    别名
    SHH (SHH 产品)
    别名
    HHG1 antibody, HLP3 antibody, HPE3 antibody, MCOPCB5 antibody, SMMCI antibody, TPT antibody, TPTPS antibody, 9530036O11Rik antibody, Dsh antibody, Hhg1 antibody, Hx antibody, Hxl3 antibody, M100081 antibody, fc83d08 antibody, shh antibody, syu antibody, vhh-1 antibody, vhh1 antibody, wu:fc83d08 antibody, Xhh antibody, hedgehog antibody, xshh antibody, SHH antibody, twh antibody, twhh antibody, sonic hedgehog antibody, sonic hedgehog a antibody, sonic hedgehog L homeolog antibody, sonic hedgehog protein A antibody, sonic hedgehog b antibody, SHH antibody, Shh antibody, shha antibody, shh.L antibody, shh antibody, shhb antibody
    背景

    Description: This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved, the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly.

    Aliases: TPT, HHG1, HLP3, HPE3, SMMCI, TPTPS, MCOPCB5, SHH

    分子量
    49.6kDa
    基因ID
    6469
    HGNC
    6469
    UniProt
    Q15465
    途径
    Hedgehog Signaling, Dopaminergic Neurogenesis, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development
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