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RSPO1 抗体

RSPO1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 7A6 unconjugated
产品编号 ABIN969375
发货至: 中国
  • 抗原 See all RSPO1 抗体
    RSPO1 (R-Spondin 1 (RSPO1))
    适用
    • 43
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    宿主
    • 47
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    • 1
    小鼠
    克隆类型
    • 48
    • 5
    单克隆
    标记
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    This RSPO1 antibody is un-conjugated
    应用范围
    • 36
    • 15
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    • 11
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    • 7
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    • 2
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    Western Blotting (WB), ELISA
    纯化方法
    purified
    免疫原
    Purified recombinant fragment of R-spondin1 expressed in E. coli.
    克隆位点
    7A6
    亚型
    IgG1
    Top Product
    Discover our top product RSPO1 Primary Antibody
  • 应用备注
    ELISA: 1:10000, WB: 1:500 - 1:2000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Ascitic fluid containing 0.03 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C/-20 °C
    储存方法
    4°C, -20°C for long term storage
  • Tomaselli, Megiorni, De Bernardo, Felici, Marrocco, Maggiulli, Grammatico, Remotti, Saccucci, Valentini, Mazzilli, Majore, Grammatico: "Syndromic true hermaphroditism due to an R-spondin1 (RSPO1) homozygous mutation." in: Human mutation, Vol. 29, Issue 2, pp. 220-6, (2008) (PubMed).

    Parma, Radi, Vidal, Chaboissier, Dellambra, Valentini, Guerra, Schedl, Camerino: "R-spondin1 is essential in sex determination, skin differentiation and malignancy." in: Nature genetics, Vol. 38, Issue 11, pp. 1304-9, (2006) (PubMed).

  • 抗原
    RSPO1 (R-Spondin 1 (RSPO1))
    别名
    R-spondin1 (RSPO1 产品)
    别名
    RGD1565558 antibody, CRISTIN3 antibody, RSPO antibody, R-spondin antibody, Rspondin antibody, wu:fj81e05 antibody, zgc:92153 antibody, R-spondin 1 antibody, Rspo1 antibody, RSPO1 antibody, LOC100049655 antibody, rspo1 antibody
    背景

    Description: R-spondin1, also known as RSPO1, CRISTIN3, FLJ40906. Entrez Protein NP_001033722.1. It is a member of the R-spondin family and a 28.9 kDa secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.It is activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination.

    Aliases: RSPO1,CRISTIN3,FLJ40906

    分子量
    28.9 kDa
    基因ID
    284654
    HGNC
    284654
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