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VEGFR2/CD309 抗体 (AA 20-764)

Name: VEGFR2/CD309 抗体 (AA 20-764)
Brand: antibodies-online
SKU: ABIN969231
Availability: OutOfStock

VEGFR2 适用: 人 ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 4B4 unconjugated

Western blot analysis using KDR mouse mAb against extracellular domain of human KDR (aa20-764). (VEGFR2/CD309 抗体 (AA 20-764))

Flow cytometric analysis of HepG2 cells using KDR mouse mAb (green) and negative control (purple). (VEGFR2/CD309 抗体 (AA 20-764))

FACS

Confocal immunofluorescence analysis of Hela (left) and HepG2 (right) cells using KDR mouse mAb (green). (VEGFR2/CD309 抗体 (AA 20-764))

3 images

(1 reference)

产品编号 ABIN969231

发货至: 中国

Datasheet as PDF

抗原 See all VEGFR2/CD309 (VEGFR2) 抗体

VEGFR2/CD309 (VEGFR2) (VEGF Receptor 2 (VEGFR2))
抗原表位
42

36

27

25

20

16

16

15

15

10

9

8

8

6

6

6

5

5

4

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 20-764
适用
312

199

145

17

9

5

3

3

3

3

1

1

1

1

1

1

1

1

1

1
人
宿主
305

50

15

1

1

1
小鼠
Compatible Secondaries
克隆类型
298

75
单克隆
标记
162

34

20

13

13

12

7

7

7

7

7

7

6

6

6

6

6

6

6

6

6

6

6

2

2

1

1

1

1

1

1

1
This VEGFR2/CD309 antibody is un-conjugated
应用范围
222

134

96

84

64

27

26

22

17

14

13

12

9

8

7

4

2

2

1
ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)

原理

KDR Antibody

纯化方法

Ascitic fluid

免疫原

Purified recombinant extracellular fragment of human KDR (aa20-764) fused with hIgGFc tag expressed in HEK293 cells.

克隆位点

4B4

亚型

IgG1

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应用备注

ELISA: 1/10000
FCM: 1/200 - 1/400
ICC: 1/200 - 1/1000

限制

仅限研究用
状态

Liquid

缓冲液

Ascitic fluid containing 0.03 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Takahashi, Yamaguchi, Chida, Shibuya: "A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells." in: The EMBO journal, Vol. 20, Issue 11, pp. 2768-78, (2001) (PubMed).
抗原

VEGFR2/CD309 (VEGFR2) (VEGF Receptor 2 (VEGFR2))

别名

KDR (VEGFR2 产品)

别名

CD309 antibody, FLK1 antibody, VEGFR antibody, VEGFR2 antibody, 6130401C07 antibody, Flk-1 antibody, Flk1 antibody, Krd-1 antibody, Ly73 antibody, VEGFR-2 antibody, sVEGFR-2 antibody, Vegfr-2 antibody, FLK-1 antibody, flk-1 antibody, vegfr-2 antibody, KDR antibody, FLK/KDR antibody, flk1 antibody, flk1b antibody, kdrb antibody, si:busm1-205d10.1 antibody, si:ch211-254j6.1 antibody, si:ch211-278f21.4 antibody, wu:fc31a09 antibody, fk52c05 antibody, flk antibody, kdr antibody, kdra antibody, vegfr2 antibody, vegfr4 antibody, vegr2 antibody, wu:fk52c05 antibody, kinase insert domain receptor antibody, kinase insert domain protein receptor antibody, vascular endothelial growth factor receptor kdr-like antibody, kinase insert domain receptor (a type III receptor tyrosine kinase) antibody, kinase insert domain receptor like antibody, KDR antibody, Kdr antibody, LOC100136647 antibody, kdr antibody, kdrl antibody

背景

Description: KDR has also been designated as VEFR-2 (Vascular endothelial growth factor receptor 2), CD309 (cluster of differentiation 309) and Flk1 (fetal liver kinase 1). Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. KDR is one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas.
Aliases: FLK1, CD309, VEGFR, VEGFR2

分子量

152kDa

基因ID

3791

HGNC

3791

UniProt

P35968

途径

RTK signaling, Glycosaminoglycan Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2, Growth Factor Binding, Regulation of long-term Neuronal Synaptic Plasticity, VEGF Signaling