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HAS1 抗体

HAS1 适用: 人 ELISA, ICC 宿主: 小鼠 Monoclonal 3E10 unconjugated
产品编号 ABIN969185
发货至: 中国
  • 抗原 See all HAS1 抗体
    HAS1 (Hyaluronan Synthase 1 (HAS1))
    适用
    • 55
    • 29
    • 22
    • 5
    • 5
    • 4
    • 2
    • 1
    宿主
    • 50
    • 6
    小鼠
    克隆类型
    • 50
    • 6
    单克隆
    标记
    • 18
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This HAS1 antibody is un-conjugated
    应用范围
    • 26
    • 24
    • 19
    • 13
    • 13
    • 6
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    ELISA, Immunocytochemistry (ICC)
    原理
    HAS1 Antibody
    纯化方法
    Ascitic fluid
    免疫原
    Purified recombinant fragment of human HAS1 expressed in E. Coli.
    克隆位点
    3E10
    亚型
    IgG1
    Top Product
    Discover our top product HAS1 Primary Antibody
  • 应用备注

    ELISA: 1/10000

    ICC: 1/200 - 1/1000

    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Ascitic fluid containing 0.03 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Stuhlmeier: "Hyaluronan production in synoviocytes as a consequence of viral infections: HAS1 activation by Epstein-Barr virus and synthetic double- and single-stranded viral RNA analogs." in: The Journal of biological chemistry, Vol. 283, Issue 24, pp. 16781-9, (2008) (PubMed).

    Adamia, Treon, Reiman, Tournilhac, McQuarrie, Mant, Belch, Pilarski: "Potential impact of a single nucleotide polymorphism in the hyaluronan synthase 1 gene in Waldenstrom's macroglobulinemia." in: Clinical lymphoma, Vol. 5, Issue 4, pp. 253-6, (2005) (PubMed).

  • 抗原
    HAS1 (Hyaluronan Synthase 1 (HAS1))
    别名
    HAS1 (HAS1 产品)
    别名
    dg42 antibody, Xhas1 antibody, HAS antibody, shas1 antibody, hyaluronan synthase 1 antibody, hyaluronan synthase 1 S homeolog antibody, has1 antibody, HAS1 antibody, Has1 antibody, has1.S antibody
    背景

    Description: Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan synthase.

    Aliases: HAS, HAS1

    分子量
    65kDa
    基因ID
    3036
    HGNC
    3036
    UniProt
    Q92839
    途径
    Glycosaminoglycan Metabolic Process
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