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- 抗原 See all FOXD3 抗体
- FOXD3 (Forkhead Box D3 (FOXD3))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This FOXD3 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 原理
- FOXD3 Antibody
- 纯化方法
- Ascitic fluid
- 免疫原
- Purified recombinant fragment of human FOXD3 expressed in E. Coli.
- 克隆位点
- 5G9
- 亚型
- IgG1
- Top Product
- Discover our top product FOXD3 Primary Antibody
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- 应用备注
- ELISA: 1/10000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Ascitic fluid containing 0.03 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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Analyses of the effects that disease-causing missense mutations have on the structure and function of the winged-helix protein FOXC1." in: American journal of human genetics, Vol. 68, Issue 3, pp. 627-41, (2001) (PubMed).
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Analyses of the effects that disease-causing missense mutations have on the structure and function of the winged-helix protein FOXC1." in: American journal of human genetics, Vol. 68, Issue 3, pp. 627-41, (2001) (PubMed).
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- 抗原
- FOXD3 (Forkhead Box D3 (FOXD3))
- 别名
- FOXD3 (FOXD3 产品)
- 背景
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Description: FoxD3 is a member of the Forkhead Box family and is characterized by a winged-helix DNA-binding structure and the important role it plays in embryonic development . This transcriptional regulator is required for the maintenance of pluripotency in the pre-implantation and peri-implantation stages of mouse embryonic development and is also required for trophoblast formation . FoxD3 is required for the maintenance of the mammalian neural crest, FoxD3(-/-) mouse embryos fail around the time of implantation with loss of neural crest-derived structures . FoxD3 also forms a regulatory network with Oct-4 and NANOG to maintain the pluripotency of ES cells .Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis .Tissue specificity: Expressed in chronic myeloid leukemia, Jurkat T-cell leukemia and teratocarcinoma cell lines, but not in any other cell lines or normal tissues examined .
Aliases: AIS1, HFH2, Genesis, FOXD3
- 分子量
- 48kDa
- 基因ID
- 27022
- HGNC
- 27022
- UniProt
- Q9UJU5
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