FAK 抗体
(2 references)-
- 抗原 See all FAK (PTK2) 抗体
- FAK (PTK2) (PTK2 Protein tyrosine Kinase 2 (PTK2))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This FAK antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)
- 纯化方法
- purified
- 免疫原
- Purified recombinant fragment of human FAK expressed in E. coli.
- 克隆位点
- 10H7E9
- 亚型
- IgG1
- Top Product
- Discover our top product PTK2 Primary Antibody
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anti-PTK2 Protein tyrosine Kinase 2 (PTK2) (pTyr397) antibody
PTK2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-PTK2 Protein tyrosine Kinase 2 (PTK2) (AA 700-800) antibodyPTK2 适用: 人 WB, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-PTK2 Protein tyrosine Kinase 2 (PTK2) (AA 798-1041) antibodyPTK2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-PTK2 Protein tyrosine Kinase 2 (PTK2) (AA 355-490) antibodyPTK2 适用: 人 WB, ELISA, IP, PLA 宿主: 小鼠 Monoclonal 2C3 unconjugated
anti-PTK2 Protein tyrosine Kinase 2 (PTK2) (pTyr576) antibodyPTK2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-PTK2 Protein tyrosine Kinase 2 (PTK2) (AA 396-423) antibodyPTK2 适用: 人 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB20775 unconjugated
anti-PTK2 Protein tyrosine Kinase 2 (PTK2) (AA 1-680) antibodyPTK2 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-PTK2 Protein tyrosine Kinase 2 (PTK2) (pTyr861) antibodyPTK2 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-PTK2 Protein tyrosine Kinase 2 (PTK2) antibodyPTK2 适用: 人, 小鼠 WB, ELISA, IHC, ICC 宿主: 小鼠 Monoclonal 10H7 unconjugated
anti-PTK2 Protein tyrosine Kinase 2 (PTK2) (C-Term) antibodyPTK2 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- ELISA: 1:10000, WB: 1:500 - 1:2000, ICC: 1:200 - 1:1000, FCM: 1:200 - 1:400
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Ascitic fluid containing 0.03 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- 4°C, -20°C for long term storage
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: "B cell receptor-induced phosphorylation of Pyk2 and focal adhesion kinase involves integrins and the Rap GTPases and is required for B cell spreading." in: The Journal of biological chemistry, Vol. 284, Issue 34, pp. 22865-77, (2009) (PubMed).
: "Targeting of the protein interaction site between FAK and IGF-1R." in: Biochemical and biophysical research communications, Vol. 388, Issue 2, pp. 301-5, (2009) (PubMed).
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: "B cell receptor-induced phosphorylation of Pyk2 and focal adhesion kinase involves integrins and the Rap GTPases and is required for B cell spreading." in: The Journal of biological chemistry, Vol. 284, Issue 34, pp. 22865-77, (2009) (PubMed).
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- 抗原
- FAK (PTK2) (PTK2 Protein tyrosine Kinase 2 (PTK2))
- 别名
- FAK (PTK2 产品)
- 别名
- FADK antibody, FAK antibody, FAK1 antibody, FRNK antibody, PPP1R71 antibody, p125FAK antibody, pp125FAK antibody, PTK2 antibody, Fadk antibody, mKIAA4203 antibody, fak antibody, fak1a antibody, ptk2 antibody, ptk2a antibody, wu:fa18c04 antibody, zgc:66114 antibody, CG10023 antibody, CT28129 antibody, DFAK antibody, DFak antibody, DFak56 antibody, Dfak antibody, Dfak56 antibody, DmFAK antibody, Dmel\\CG10023 antibody, Fak56 antibody, Fak56D antibody, fak56 antibody, protein tyrosine kinase 2 antibody, protein tyrosine kinase 2 L homeolog antibody, PTK2 protein tyrosine kinase 2 antibody, protein tyrosine kinase 2ab antibody, Focal adhesion kinase antibody, PTK2 antibody, ptk2.L antibody, Ptk2 antibody, ptk2ab antibody, Fak antibody
- 背景
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Description: This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. At least four transcript variants encoding four different isoforms have been found for this gene, but the full-length natures of only two of them have been determined. Tissue specificity: Expressed in all organs tested, in lymphoid cell lines, but most abundantly in brain.RD: Focal adhesion kinase 1 (FAK) is a ubiquitously expressed non-receptor protein tyrosine kinase that is concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. This cellular localization is directed by a ""Focal Adhesion Targeting"" (FAT) sequence, a 125 amino acid sequence at the C-terminus. FAK plays an important role in migration, cell spreading, differentiation, cytoskeleton protein phosphorylation, apoptosis and acceleration of the G1 to S phase transition of the cell cycle. It associates with several different signaling proteins such as Src-family PTKs, p130Cas, Shc, Grb2, PI 3-kinase, and paxillin. This enables FAK to function within a network of integrin-stimulated signaling pathways leading to the activation of targets such as the ERK and JNK/mitogen-activated protein kinase pathways. FAK is also linked to oncogenes at biochemical and functional levels. Increased expression and/or activity of FAK in various tumors has been correlated with enhanced migration and invasiveness of human tumor cells in addition to promoting increased cell proliferation.
Aliases: FAK, FADK, FAK1, FRNK, pp125FAK, PTK2
- 分子量
- 119 kDa
- 基因ID
- 5747
- HGNC
- 5747
- 途径
- Response to Growth Hormone Stimulus, CXCR4-mediated Signaling Events, Smooth Muscle Cell Migration, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling
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