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- 抗原 See all CSK 抗体
- CSK (C-Src tyrosine Kinase (CSK))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This CSK antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS)
- 原理
- CSK Antibody
- 纯化方法
- Ascitic fluid
- 免疫原
- Purified recombinant fragment of human CSK expressed in E. Coli.
- 克隆位点
- 5F3
- 亚型
- IgG1
- Top Product
- Discover our top product CSK Primary Antibody
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- 应用备注
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ELISA: 1/10000
FCM: 1/200 - 1/400
ICC: 1/200 - 1/1000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Ascitic fluid containing 0.03 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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Genome-wide association study of blood pressure and hypertension. ..." in: Nature genetics, Vol. 41, Issue 6, pp. 677-87, (2010) (PubMed).
: "Discovery and replication of novel blood pressure genetic loci in the Women's Genome Health Study." in: Journal of hypertension, Vol. 29, Issue 1, pp. 62-9, (2010) (PubMed).
: "A high-throughput candidate gene mutation screen in lymphoproliferative and myeloproliferative neoplasias." in: Leukemia research, Vol. 33, Issue 9, pp. e168-9, (2009) (PubMed).
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Genome-wide association study of blood pressure and hypertension. ..." in: Nature genetics, Vol. 41, Issue 6, pp. 677-87, (2010) (PubMed).
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- 抗原
- CSK (C-Src tyrosine Kinase (CSK))
- 别名
- CSK (CSK 产品)
- 别名
- AW212630 antibody, C-terminal Src kinase antibody, c-src tyrosine kinase antibody, CSK, non-receptor tyrosine kinase antibody, CSK antibody, Csk antibody
- 背景
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Description: Carboxy-terminal Src kinase (Csk) is a ubiquitously expressed nonreceptor tyrosine kinase that negatively regulates the Src family kinases (SFK) by phosphorylation of the SFK carboxy-terminal tyrosine. Phosphorylated carboxy-terminal tyrosine binds to the SH2 domain of SFK intramolecularly and leads to folding and inactivation of the SFK . This Csk-catalyzed SFK tyrosine phosphorylation is highly specific and exclusive. The SFK carboxy-terminal tyrosine is the only known physiological substrate of Csk .Tissue specificity: Expressed in lung and macrophages.
Aliases: MGC117393, CSK
- 分子量
- 50kDa
- 基因ID
- 1445
- HGNC
- 1445
- UniProt
- P41240
- 途径
- TCR Signaling, EGFR Signaling Pathway, Cell-Cell Junction Organization, CXCR4-mediated Signaling Events
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