CRTC1 抗体
(3 references)-
- 抗原 See all CRTC1 抗体
- CRTC1 (CREB Regulated Transcription Coactivator 1 (CRTC1))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This CRTC1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)
- 原理
- CRTC1 Antibody
- 纯化方法
- Ascitic fluid
- 免疫原
- Purified recombinant fragment of human CRTC1 expressed in E. Coli.
- 克隆位点
- 1B5
- 亚型
- IgG1
- Top Product
- Discover our top product CRTC1 Primary Antibody
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anti-CREB Regulated Transcription Coactivator 1 (CRTC1) (pSer151) antibody
CRTC1 适用: 人, 小鸡 WB, ELISA, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-CREB Regulated Transcription Coactivator 1 (CRTC1) antibodyCRTC1 适用: 人 WB, IP, FACS, ICC 宿主: 小鼠 Monoclonal unconjugated
anti-CREB Regulated Transcription Coactivator 1 (CRTC1) (AA 1-248) antibodyCRTC1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-CREB Regulated Transcription Coactivator 1 (CRTC1) antibodyCRTC1 适用: 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-CREB Regulated Transcription Coactivator 1 (CRTC1) (AA 553-634) antibodyCRTC1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 8F9 unconjugated
anti-CREB Regulated Transcription Coactivator 1 (CRTC1) antibodyCRTC1 适用: 人, 小鼠 WB, ICC 宿主: 小鼠 Monoclonal unconjugated
anti-CREB Regulated Transcription Coactivator 1 (CRTC1) antibodyCRTC1 适用: 人, 小鼠, 大鼠 WB, IF (p), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-CREB Regulated Transcription Coactivator 1 (CRTC1) (AA 1-200) antibodyCRTC1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-CREB Regulated Transcription Coactivator 1 (CRTC1) (AA 19-34) antibodyCRTC1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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ELISA: 1/10000
FCM: 1/200 - 1/400
ICC: 1/200 - 1/1000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Ascitic fluid containing 0.03 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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: "Stimulation by lithium of the interaction between the transcription factor CREB and its co-activator TORC." in: Bioscience reports, Vol. 29, Issue 2, pp. 77-87, (2009) (PubMed).
: "A closer look at Warthin tumors and the t(11;19)." in: Cancer genetics and cytogenetics, Vol. 180, Issue 2, pp. 135-9, (2008) (PubMed).
: "Frequent fusion of the CRTC1 and MAML2 genes in clear cell variants of cutaneous hidradenomas." in: Genes, chromosomes & cancer, Vol. 46, Issue 6, pp. 559-63, (2007) (PubMed).
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: "Stimulation by lithium of the interaction between the transcription factor CREB and its co-activator TORC." in: Bioscience reports, Vol. 29, Issue 2, pp. 77-87, (2009) (PubMed).
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- 抗原
- CRTC1 (CREB Regulated Transcription Coactivator 1 (CRTC1))
- 别名
- CRTC1 (CRTC1 产品)
- 别名
- MECT1 antibody, TORC-1 antibody, TORC1 antibody, WAMTP1 antibody, AI413414 antibody, Mect1 antibody, R74955 antibody, mKIAA0616 antibody, CRTC1 antibody, crtc1 antibody, fc68c05 antibody, pde4cb antibody, si:ch211-255d18.1 antibody, si:ch211-255d18.8 antibody, wu:fc68c05 antibody, CREB regulated transcription coactivator 1 antibody, CREB regulated transcription coactivator 1b antibody, CRTC1 antibody, Crtc1 antibody, crtc1 antibody, crtc1b antibody
- 背景
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Description: MECT1 (also known as MucoEpidermoid Carcinoma Translocated 1) functions as a transcriptional coactivator for CREB1, which activates transcription through both consensus and variant cAMP response element (CRE) sites. MECT1 does not appear to modulate CREB1 DNA-binding activity but enhances the interaction of CREB1 with TAF4/TAFII-130. MECT1 translocates with MAML2 (MasterMind-Like Protein 2) to yield a fusion oncogene: t(11,19) (q21,p13). This translocation occurs in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. The novel fusion product that results disrupts the Notch signaling pathway. The fusion protein consists of the N-terminus of MECT1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of MECT1 has been detected in a small number of mucoepidermoid carcinomas. Multiple isoforms have been reported for the MECT1 protein. Tissue specificity: Highly expressed in adult and fetal brain. Located to specific regions such as the prefrontal cortex and cerebellum. Very low expression in other tissues such as heart, spleen, lung, skeletal muscle, salivary gland, ovary and kidney.
Aliases: MECT1, TORC1, WAMTP1, FLJ14027, KIAA0616, CRTC1
- 分子量
- 67kDa
- 基因ID
- 23373
- HGNC
- 23373
- UniProt
- Q6UUV9
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