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- 抗原 See all CDKN1B 抗体
- CDKN1B (Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This CDKN1B antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 纯化方法
- purified
- 免疫原
- Purified recombinant fragment of human CDKN1B expressed in E. coli.
- 克隆位点
- 3D8
- 亚型
- IgG1
- Top Product
- Discover our top product CDKN1B Primary Antibody
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- 应用备注
- ELISA: 1:10000, WB: 1:500 - 1:2000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Ascitic fluid containing 0.03 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- 4°C, -20°C for long term storage
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The function of p27 KIP1 during tumor development." in: Experimental & molecular medicine, Vol. 41, Issue 11, pp. 765-71, (2009) (PubMed).
: "Cytoplasmic p27 expression is an independent prognostic factor in ovarian cancer." in: International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists, Vol. 29, Issue 1, pp. 8-18, (2009) (PubMed).
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The function of p27 KIP1 during tumor development." in: Experimental & molecular medicine, Vol. 41, Issue 11, pp. 765-71, (2009) (PubMed).
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- 抗原
- CDKN1B (Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B))
- 别名
- CDKN1B (CDKN1B 产品)
- 别名
- CDKN4 antibody, KIP1 antibody, MEN1B antibody, MEN4 antibody, P27KIP1 antibody, cdkn1b antibody, sb:cb611 antibody, wu:fb63g10 antibody, wu:fb64g10 antibody, wu:fe18e03 antibody, CDKN1B antibody, Kip1 antibody, p27 antibody, FAM14D antibody, ISG12 antibody, ISG12A antibody, P27 antibody, Cdki1b antibody, AA408329 antibody, AI843786 antibody, p27Kip1 antibody, cdkn1bl antibody, cyclin dependent kinase inhibitor 1B antibody, cyclin-dependent kinase inhibitor 1Bb antibody, interferon alpha inducible protein 27 antibody, cyclin-dependent kinase inhibitor 1B antibody, cyclin-dependent kinase inhibitor 1Ba antibody, CDKN1B antibody, cdkn1bb antibody, IFI27 antibody, Cdkn1b antibody, cdkn1ba antibody
- 背景
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Description: p27 KIP 1 is a cell cycle regulatory mitotic inhibitor of cdk activity. p27 KIP 1 is a candidate tumor suppressor gene, and has been proposed to function as a possible mediator of TGF beta induced G1 arrest. p27 KIP 1 is up regulated in response to antimitogenic stimuli. The increased protein expression of p27 results in cellular arrest by binding to cyclin/Cdk complexes such as cyclin D1/Cdk4. Decreased levels of p27Kip1, mainly due to proteosomal degradation, are found in various epithelial tumors originating from lung, breast, colon, ovary, esophagus, thyroid and prostate.Tissue specificity: Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney.
Aliases: KIP1, MEN4, CDKN4, MEN1B, P27KIP1, CDKN1B
- 分子量
- 22 kDa
- 基因ID
- 1027
- HGNC
- 1027
- 途径
- Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Negative Regulation of Hormone Secretion, Sensory Perception of Sound, Mitotic G1-G1/S Phases, DNA Replication, Positive Regulation of Endopeptidase Activity, Synthesis of DNA, Autophagy
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