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BPTF 抗体

BPTF 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2F10 unconjugated
产品编号 ABIN968990
发货至: 中国
  • 抗原 See all BPTF 抗体
    BPTF (Bromodomain PHD Finger Transcription Factor (BPTF))
    适用
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    宿主
    • 21
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    小鼠
    克隆类型
    • 21
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    单克隆
    标记
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    • 1
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    This BPTF antibody is un-conjugated
    应用范围
    • 19
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    Western Blotting (WB), ELISA
    纯化方法
    purified
    免疫原
    Purified recombinant fragment of human BPTF expressed in E. coli.
    克隆位点
    2F10
    亚型
    IgG2b
    Top Product
    Discover our top product BPTF Primary Antibody
  • 应用备注
    ELISA: 1:10000, WB: 1:500 - 1:2000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Ascitic fluid containing 0.03 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C/-20 °C
    储存方法
    4°C, -20°C for long term storage
  • Landry, Sharov, Piao, Sharova, Xiao, Southon, Matta, Tessarollo, Zhang, Ko, Kuehn, Yamaguchi, Wu: "Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cells." in: PLoS genetics, Vol. 4, Issue 10, pp. e1000241, (2008) (PubMed).

    Barbe, Lundberg, Oksvold, Stenius, Lewin, Björling, Asplund, Pontén, Brismar, Uhlén, Andersson-Svahn: "Toward a confocal subcellular atlas of the human proteome." in: Molecular & cellular proteomics : MCP, Vol. 7, Issue 3, pp. 499-508, (2008) (PubMed).

  • 抗原
    BPTF (Bromodomain PHD Finger Transcription Factor (BPTF))
    别名
    BPTF (BPTF 产品)
    别名
    FAC1 antibody, FALZ antibody, NURF301 antibody, 9430093H17Rik antibody, Falz antibody, BPTF antibody, bromodomain PHD finger transcription factor antibody, nucleosome-remodeling factor subunit NURF301 antibody, fetal alzheimer antigen, falz antibody, BPTF antibody, Bptf antibody, LOC5576547 antibody, CpipJ_CPIJ011285 antibody, bptf antibody
    背景

    Description: BPTF (bromodomain and PHD domain transcription factor) is the largest subunit of the ATP-dependent chromatin-remodelling complex, NURF (nucleosome remodelling factor). NURF catalyses ATP-dependent nucleosome sliding and facilitates transcription. BPTF recognises histone H3 tails that are tri-methylated at K4, which marks the transcriptional start site of the vast majority of transcriptionally active genes. BPTF also exhibits some binding to H3 di-methylated at K4. BPTF plays a key role in the development of early mouse embryos, possibly through regulation of the Smad pathway of transcription factors. While BPTF is expressed in low levels in the adult brain and spinal cord, it is expressed in higher levels in the brain in neurodegenerative diseases. It is present in a subset of amyloid-containing plaques in the brains of patients suffering from Alzheimer's disease. Abundantly expressed in the fetal brain. Present throughout the gray and white matter of the developing spinal cord at 18-22 gestational weeks. Expressed at low levels in adult brain and spinal cord and reexpressed in neurodegenerative diseases (at protein level) .Tissue specificity: Ubiquitously expressed, with highest levels in testis. Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex (at protein level).

    Aliases: FAC1, FALZ, NURF301, BPTF

    分子量
    338 kDa
    基因ID
    2186
    HGNC
    2186
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