OPA1 抗体 (AA 708-830)
(3 references)-
- 抗原 See all OPA1 抗体
- OPA1 (Optic Atrophy 1 (Autosomal Dominant) (OPA1))
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抗原表位
- AA 708-830
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适用
- 人, 小鼠, 大鼠, 小鸡, 犬
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This OPA1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF)
- 交叉反应
- 犬, 大鼠, 小鼠, 小鸡
- 产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Human OPA1 aa. 708-830
- 克隆位点
- 18-OPA1
- 亚型
- IgG1
- Top Product
- Discover our top product OPA1 Primary Antibody
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anti-Optic Atrophy 1 (Autosomal Dominant) (OPA1) (AA 661-960) antibody
OPA1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Optic Atrophy 1 (Autosomal Dominant) (OPA1) (AA 851-960) antibodyOPA1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 8A20 unconjugated
anti-Optic Atrophy 1 (Autosomal Dominant) (OPA1) (AA 919-955), (C-Term) antibodyOPA1 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Optic Atrophy 1 (Autosomal Dominant) (OPA1) (AA 651-750) antibodyOPA1 适用: 人, 小鼠, 大鼠, 小鸡, 兔 WB, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Optic Atrophy 1 (Autosomal Dominant) (OPA1) (AA 183-418) antibodyOPA1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Optic Atrophy 1 (Autosomal Dominant) (OPA1) (AA 1-960) antibodyOPA1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Optic Atrophy 1 (Autosomal Dominant) (OPA1) (AA 1-960) antibodyOPA1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Optic Atrophy 1 (Autosomal Dominant) (OPA1) (AA 183-351) antibodyOPA1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Optic Atrophy 1 (Autosomal Dominant) (OPA1) (AA 851-960) antibodyOPA1 适用: 人 ELISA 宿主: 小鼠 Monoclonal 1C10 unconjugated
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- 说明
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Related Products: ABIN968586, ABIN967389
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 250 μg/mL
- 缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store undiluted at -20° C.
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: "Primary structure of a dynamin-related mouse mitochondrial GTPase and its distribution in brain, subcellular localization, and effect on mitochondrial morphology." in: The Journal of biological chemistry, Vol. 277, Issue 18, pp. 15834-42, (2002) (PubMed).
: "OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28." in: Nature genetics, Vol. 26, Issue 2, pp. 211-5, (2000) (PubMed).
: "Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy." in: Nature genetics, Vol. 26, Issue 2, pp. 207-10, (2000) (PubMed).
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: "Primary structure of a dynamin-related mouse mitochondrial GTPase and its distribution in brain, subcellular localization, and effect on mitochondrial morphology." in: The Journal of biological chemistry, Vol. 277, Issue 18, pp. 15834-42, (2002) (PubMed).
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- 抗原
- OPA1 (Optic Atrophy 1 (Autosomal Dominant) (OPA1))
- 别名
- OPA1 (OPA1 产品)
- 别名
- 1200011N24Rik antibody, AI225888 antibody, AI847218 antibody, lilr3 antibody, mKIAA0567 antibody, MGM1 antibody, NPG antibody, NTG antibody, largeG antibody, fk62d06 antibody, wu:fb77a10 antibody, wu:fk62d06 antibody, zgc:92092 antibody, OPA1, mitochondrial dynamin like GTPase antibody, optic atrophy 1 (autosomal dominant) antibody, Opa1 antibody, OPA1 antibody, opa1 antibody
- 背景
- Three major GTP-binding protein families include trimeric and low molecular weight G-proteins, as well as a family of large proteins homologous to dynamin. The dynamin family contains proteins with diverse structure and function, but highly homologous N-terminal GTPase domains. A subgroup of the dynamin G-protein-binding family includes the mitochondrial proteins Drp1/Dnm1, Mgm1, and OPA1. The latter protein is mutated in dominant optic atrophy, a disease that involves loss of visual acuity and atrophy of the optic nerve. OPA1 is expressed in heart, brain, liver, and kidney. The sequence of OPA1 includes an N-terminal region that contains a mitochondrial targeting domain and three GTP-binding motifs. The overexpression of OPA1 in Cos-7 cells shows co-localization with cytochrome c in mitochondria, and leads to alterations in mitochondrial morphology from a characteristic tubuluar shape to a vesicular pattern. Thus, OPA1 may have roles in mitochondrial biogenesis that are critical for normal cell function. This antibody is routinely tested by western blot analysis.
- 分子量
- 80-100 kDa
- 途径
- Tube Formation
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