DDB1 抗体 (AA 739-935)
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- 抗原 See all DDB1 抗体
- DDB1 (Damage Specific DNA Binding Protein 1 (DDB1))
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抗原表位
- AA 739-935
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适用
- 人, 小鼠, 大鼠, 犬
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This DDB1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF)
- 交叉反应
- 大鼠, 小鼠, 犬
- 产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Human DDB1 aa. 739-935
- 克隆位点
- 8-DDB1
- 亚型
- IgG1
- Top Product
- Discover our top product DDB1 Primary Antibody
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anti-Damage Specific DNA Binding Protein 1 (DDB1) (C-Term) antibody
Verified DDB1 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Damage Specific DNA Binding Protein 1 (DDB1) (C-Term) antibodyKO Validated DDB1 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Damage Specific DNA Binding Protein 1 (DDB1) antibodyDDB1 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Damage Specific DNA Binding Protein 1 (DDB1) (C-Term) antibodyDDB1 适用: 人 WB, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-Damage Specific DNA Binding Protein 1 (DDB1) antibodyDDB1 适用: 人 WB, IHC, IP 宿主: 兔 Monoclonal unconjugated
anti-Damage Specific DNA Binding Protein 1 (DDB1) (AA 1011-1140) antibodyDDB1 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Damage Specific DNA Binding Protein 1 (DDB1) (AA 1011-1140) antibodyDDB1 适用: 人, 小鼠, 大鼠 WB, IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Damage Specific DNA Binding Protein 1 (DDB1) (AA 1044-1140) antibodyDDB1 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 4C5 unconjugated
anti-Damage Specific DNA Binding Protein 1 (DDB1) (C-Term) antibodyDDB1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Damage Specific DNA Binding Protein 1 (DDB1) antibodyDDB1 适用: 人 WB, ELISA, IHC, IHC (p), IP 宿主: 小鼠 Monoclonal unconjugated
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- 说明
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Related Products: ABIN968535, ABIN967389
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 250 μg/mL
- 缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store undiluted at -20° C.
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: "Sequential binding of UV DNA damage binding factor and degradation of the p48 subunit as early events after UV irradiation." in: Nucleic acids research, Vol. 30, Issue 11, pp. 2588-98, (2002) (PubMed).
: "Identification of rat DDB1, a putative DNA repair protein, and functional correlation with its damaged-DNA recognition activity." in: Journal of biomedical science, Vol. 9, Issue 4, pp. 371-80, (2002) (PubMed).
: "Characterization of DNA recognition by the human UV-damaged DNA-binding protein." in: The Journal of biological chemistry, Vol. 274, Issue 28, pp. 20027-33, (1999) (PubMed).
: "Chromosomal localization and cDNA cloning of the genes (DDB1 and DDB2) for the p127 and p48 subunits of a human damage-specific DNA binding protein." in: Genomics, Vol. 29, Issue 1, pp. 62-9, (1996) (PubMed).
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: "Sequential binding of UV DNA damage binding factor and degradation of the p48 subunit as early events after UV irradiation." in: Nucleic acids research, Vol. 30, Issue 11, pp. 2588-98, (2002) (PubMed).
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- 抗原
- DDB1 (Damage Specific DNA Binding Protein 1 (DDB1))
- 别名
- DDB1 (DDB1 产品)
- 别名
- DDBA antibody, UV-DDB1 antibody, XAP1 antibody, XPCE antibody, XPE antibody, XPE-BF antibody, DDB1 antibody, xpe antibody, ddba antibody, xap1 antibody, xpce antibody, xpe-bf antibody, uv-ddb1 antibody, ddb1 antibody, 127kDa antibody, AA408517 antibody, p127-Ddb1 antibody, damage specific DNA binding protein 1 antibody, damage-specific DNA binding protein 1, 127kDa antibody, DNA damage-binding protein 1 antibody, damage-specific DNA binding protein 1 antibody, DDB1 antibody, ddb1 antibody, LOC100187356 antibody, Ddb1 antibody, ddb-1 antibody
- 背景
- DNA lesions caused by chemical mutagens or radiation are corrected via nucleotide excision repair (NER). The NER system includes multiple proteins involved in xeroderma pigmentosum (XP) disorders, a pathology that causes hypersensitivity to sunlight and higher incidence of skin cancer. The proteins that cause these disorders are XP proteins and include XPA, XPB, XPC, XPD, XPF, and XPG. There are six repair complexes in the NER system composed of 15-18 proteins that include XPA, XPC, XPF, TFIIH, and hHR23B. In addition to these proteins, UV damage DNA-binding (UV-DDB) protein activity has also been associated with the NER system due to the fact that UV-DDB activity is absent in a subset of XPE Ddb- patients. UV-DDB consists of two subunits, DDB1 and DDB2, which can be injected into XPE cells to restore DNA repair synthesis. UV-DDB activity may be involved in the early stages of NER when it may promote recognition of the damaged DNA through DDB2. In addition, DDB1 can bind the histone acetyltransferase p300, which may be important for chromatin remodeling during the early stages of NER. Thus, UV-DDB activity may be important for recognition of specific types of DNA damage during NER.
- 分子量
- 127 kDa
- 途径
- DNA Damage Repair
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