HERC2 抗体 (AA 1781-1974)
HERC2
适用: 人, 小鼠, 大鼠
WB
宿主: 小鼠
Monoclonal
17-HERC2
unconjugated
1 image
(2 references)-
- 抗原 See all HERC2 抗体
- HERC2 (Hect Domain and RLD 2 (HERC2))
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抗原表位
- AA 1781-1974
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适用
- 人, 小鼠, 大鼠
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This HERC2 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 交叉反应
- 人, 大鼠
- 产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Mouse HERC2 aa. 1781-1974
- 克隆位点
- 17-HERC2
- 亚型
- IgG1
- Top Product
- Discover our top product HERC2 Primary Antibody
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anti-Hect Domain and RLD 2 (HERC2) (AA 4784-4834) antibody
HERC2 适用: 人, 小鼠, 大鼠, 小鸡, Cow, 犬, 非洲爪蟾, 斑马鱼 WB, IHC (p), IP, IHC 宿主: 兔 Polyclonal unconjugated
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- 说明
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Related Products: ABIN967389
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 250 μg/mL
- 缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store undiluted at -20°C.
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: "Structure of the highly conserved HERC2 gene and of multiple partially duplicated paralogs in human." in: Genome research, Vol. 10, Issue 3, pp. 319-29, (2000) (PubMed).
: "A very large protein with diverse functional motifs is deficient in rjs (runty, jerky, sterile) mice." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 16, pp. 9436-41, (1998) (PubMed).
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: "Structure of the highly conserved HERC2 gene and of multiple partially duplicated paralogs in human." in: Genome research, Vol. 10, Issue 3, pp. 319-29, (2000) (PubMed).
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- 抗原
- HERC2 (Hect Domain and RLD 2 (HERC2))
- 别名
- HERC2 (HERC2 产品)
- 别名
- CG11734 antibody, Dmel\\CG11734 antibody, D15F32S1h antibody, D7H15F32S1 antibody, D7H15F37S1 antibody, jdf2 antibody, mKIAA0393 antibody, rjs antibody, D15F37S1 antibody, SHEP1 antibody, p528 antibody, HECT and RLD domain containing protein 2 antibody, HECT and RLD domain containing E3 ubiquitin protein ligase 2 antibody, HERC2 antibody, Herc2 antibody
- 背景
- Prader-Willi and Angelman syndromes are genetic disorders that result from recombination between chromsome-specific low-copy repeats (duplicons). ERC2(rjs) is the transcript found in the duplicon for these disorders, and recessive mutation of HERC2 leads to a developmental syndrome in mice, referred to as runty jerky sterile (rjs) and juvenile development and fertility 2 (jdf2). HERC2 is homologous to the HERC1 and HERC3 HECT-domain containing proteins. The sequence of HERC2 includes three RCC1-like domains (RLD), a C-terminal ECT domain, and a ZZ-type zinc finger. The RCC1 repeats are similar to those found in cytochrome b5 and the HECT domain is found in E6-AP ubiquitin ligase. HERC2 may function as both a guanine nucleotide exchange factor and E3 biquitin ligase based on its conserved motifs and observation from mouse mutation studies. HERC2 mRNA is expressed highest in brain and testes, but is also found in heart, lung, liver, skeletal muscle, and kidney. Thus, HERC2 may function in protein trafficking and degradation pathways in various tissues.
- 分子量
- 527 kDa
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