TCAP 抗体 (AA 1-167)
(4 references)-
- 抗原 See all TCAP 抗体
- TCAP (Titin-Cap (Telethonin) (TCAP))
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抗原表位
- AA 1-167
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适用
- 人, 小鼠, 大鼠
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This TCAP antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 交叉反应
- 人, 大鼠
- 产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Mouse Telethonin aa. 1-167
- 克隆位点
- 53-Telethonin
- 亚型
- IgG1
- Top Product
- Discover our top product TCAP Primary Antibody
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anti-Titin-Cap (Telethonin) (TCAP) (AA 1-167) antibody
TCAP 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1H3 unconjugated
anti-Titin-Cap (Telethonin) (TCAP) (AA 1-167) antibodyTCAP 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Titin-Cap (Telethonin) (TCAP) antibodyTCAP 适用: 人, 小鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Titin-Cap (Telethonin) (TCAP) (AA 1-167) antibodyTCAP 适用: 人 ELISA 宿主: 小鼠 Monoclonal 2B1 unconjugated
anti-Titin-Cap (Telethonin) (TCAP) (N-Term) antibodyTCAP 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Titin-Cap (Telethonin) (TCAP) antibodyTCAP 适用: 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Titin-Cap (Telethonin) (TCAP) antibodyTCAP 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-Titin-Cap (Telethonin) (TCAP) (AA 1-100) antibodyTCAP 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1A3 unconjugated
anti-Titin-Cap (Telethonin) (TCAP) (C-Term) antibodyTCAP 适用: 人, 小鼠, Cow, 犬, 豚鼠, 马, 兔, Hamster, Pig, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Titin-Cap (Telethonin) (TCAP) (AA 38-87) antibodyTCAP 适用: 人, 小鼠, Cow, Hamster, Pig, 猴 WB 宿主: 兔 Polyclonal unconjugated
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- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 250 μg/mL
- 缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store undiluted at -20°C.
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: "Early and selective disappearance of telethonin protein from the sarcomere in neurogenic atrophy." in: Journal of muscle research and cell motility, Vol. 22, Issue 3, pp. 259-64, (2001) (PubMed).
: "Limb-girdle muscular dystrophy type 2G is caused by mutations in the gene encoding the sarcomeric protein telethonin." in: Nature genetics, Vol. 24, Issue 2, pp. 163-6, (2000) (PubMed).
: "The novel sarcomeric protein telethonin exhibits developmental and functional regulation." in: Biochemical and biophysical research communications, Vol. 257, Issue 3, pp. 699-703, (1999) (PubMed).
: "Telethonin, a novel sarcomeric protein of heart and skeletal muscle." in: FEBS letters, Vol. 415, Issue 2, pp. 163-8, (1997) (PubMed).
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: "Early and selective disappearance of telethonin protein from the sarcomere in neurogenic atrophy." in: Journal of muscle research and cell motility, Vol. 22, Issue 3, pp. 259-64, (2001) (PubMed).
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- 抗原
- TCAP (Titin-Cap (Telethonin) (TCAP))
- 别名
- Telethonin (TCAP 产品)
- 别名
- TCAP antibody, CMD1N antibody, LGMD2G antibody, T-cap antibody, TELE antibody, telethonin antibody, AI503981 antibody, AJ223855 antibody, titin-cap antibody, titin-cap (telethonin) antibody, titin-cap S homeolog antibody, TCAP antibody, tcap antibody, tcap.S antibody, Tcap antibody
- 背景
- Autosomal recessive limb-girdle muscular dystrophy (AR LGMD), a genetically heterogeneous group of disorders affecting the proximal musculature, has eight distinct forms: 2A to 2H. Each of these forms is caused by specific gene mutations. A mutation in the telethonin gene causes LGMD 2G. Telethonin, a 19 kDa sarcomeric protein found in striated and cardiac muscle, has a developmentally and functionally regulated expression pattern. Telethonin transcript down-regulation occurs in response to muscle denervation. Protein levels of telethonin are partially regulated by neuronal activity, thereby linking telethonin to dynamic control of myofibrillogenesis and muscle turnover in human skeletal muscle. The telethonin transcript exhibits a pattern of accumulation typical of contractile proteins, suggesting a role for the protein in myofibrillar assembly. Immunofluorescence images show that telethonin co-localizes with myosin, which is an expression pattern typical of sarcomeric proteins. Telethonin has a known sarcomeric binding partner, titin, and is also known as titin CAP (TCAP). Therefore, telethonin plays a major role in AR LGMD 2G and is also important as a developmentally and functionally regulated sarcomeric protein.
- 分子量
- 19 kDa
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